Description
To study RYBP function during mouse development we \r\nhave generated (in collaboration with Dr. H. Koseki, Yokohama) a \r\nmouse mutant line in which coding sequences of the RYBP gene have \r\nbeen deleted.  We have seen that the deficiency of RYBP results \r\nin embryonic lethality due, at least in part, to placentation defects. Mice \r\nwith half dosage of RYBP showed moderate alterations in the axial \r\nskeleton which are modified in the absence of Ring1A. These results, \r\ntogether with the binding of RYBP to Hox gene chromatin, show that \r\nRYBP also acts as a PcG gene.