Candidates are sought to carry out the TFM in the Laboratory Functions of chemotactic receptors and the immunological synapse in dendritic cells.
IP José Luis Rodríguez-Fernández
Dendritic cells (DCs) are potent antigen-presenting cells that play an important role in the immune response. DCs migrate to lymph nodes where they present antigens to T cells, a key process in the adaptive immune response. The chemokine receptor CCR7 directs DCs to lymph nodes where T cell activation takes place. Therefore, this receptor plays a key role in the immune response.
In the laboratory, we study the mechanism used by CCR7 to regulate the effector functions of DCs. This knowledge is important to be able to modulate the function of these cells during the adaptive immune response. The student who will join this TFM project will work on the aforementioned project. The student will learn to work with cell cultures, perform immunoblots and immunofluorescence, transfections, perform chemotaxis and cell motility analysis, immunoprecipitation, and other basic techniques of cell and molecular biology.
Additional information can be found on the group webpage.
If interested, contact Dr. José Luis Rodríguez here.