The Polycomb group (PcG) of genes, an evolutionary conserved set of chromatin modifiers, is characteristically associated with the maintenance of transcriptionally repressed states relevant to cell identity. The products of the PcG genes form multiprotein complexes whose activity in transcriptional control is mediated, at least in part, by the histone modifier activities of some of their subunits. In addition to their function during embryogenesis, Polycomb complexes play roles in adult stem cells relevant to normal tissue regeneration and cancer. The lab focuses on the function of Polycomb complexes containig Ring1A and Ring1B, the E3 ligases involved in monoubiquitylation of histone H2A, recently identified as players in events of transcriptional activation.
Giner-Laguarda, N. and Vidal, M.
Epigenomes 4 (3) 17
. Functions of Polycomb Proteins on Active Targets
Yakushiji-Kaminatsui, N., Kondo, T., Hironaka, K., Sharif, J., Endo, T. A., Nakayama, M., Masui, O., Koseki, Y., Kondo, K., Ohara, O., Vidal, M., Morishita, Y. and Koseki, H.
. Variant PRC1 competes with retinoic acid-related signals to repress Meis2 in distal forelimb bud
Neira J. L., López, M. B., Sevilla, P., Rizzuti, B., Cámara-Artigas, A., Vidal, M. and Iovanna, J. L.
Biochem. J. 475:2271-2291
. The chromatin nuclear protein NUPR1L is intrinsically disordered and binds to the same proteins as its paralogue
V., Surtel, D. A. M., Kruitz, F., Kuijer, R., Takihara, Y., Marks, H., Stunnenberg, H. G., Wouters, B. G., Vidal, M. and Voncken, J. W. . PRC1 Prevents Replication Stress during Chondrogenic Transit Amplification
Santofimia-Castaño, P., Rizzuti, B., Pey, A. L., Soubeyran, P., Vidal, M., Urrutia, R., Iovanna, J. L. And Neira, J. L. . The Intrinsically Disordered Chromatin Protein NUPR1 Binds to the C-terminal Region of Polycomb RING1B
Maezawa, S., Hasegawa, K., Yukawa, M., Sakashita, A., Alavattam, K. G., Andreassen, P. R., Vidal, M., Koseki, H., Barski, A. and Namekawa, S. H. . Polycomb directs timely activation of germline genes in spermatogenesis
Vidal, M. and Starowicz, K. . Polycomb complexes PRC1 and their function in hematopoiesis Exp. Hematol. 48:1231
Ikawa,T., Masuda, K., Endo, T.A., Endo,M., Isono, K., Koseki, Y., Nakagawa, R., Kometani, K., Takano,Y., Agata, Y., Katsura, Y., Kurosaki, T.,Vidal, M., Koseki, H. and Kawamoto, H. . Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program. Genes & Dev. 30:2475-2485
ARCH consortium H2020-MSCA-ITN-2018 (2019-2023)