Publications | Centro de Investigaciones Biológicas Margarita Salas - CIB Margarita Salas

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Rai, A.; Liu, T.; Glauser, S.; Katrukha, E.A.; Estévez-Gallego, J.; Rodríguez-García, R.; Fang, W.S.; Díaz, J.F.; Steinmetz,M.O.; Altmann, K.H.; Kapitein, L.C.; Moore, C.A.; Akhmanova, A. [2019]. Taxanes convert regions of perturbed microtubule growth into rescue sites (2019) Nature Materials https://doi.org/10.1038/s41563-019-0546-6

Bonandi, E.; Foschi, F.; Dapiaggi, F.; Sironi, M.; Pieraccini, S.; Christodoulou, M.S.; Balaguer, F.A.; Díaz, J.F.; Zidar, N.; Passarella, D. [2019]. Synthesis of thicolchicine-based conjugates: investigation towards bivalent tubulin/microtubules binders ChemPlusChem 84, 98–102

La Sala, G., Olieric,N.; Sharma, A.; Viti, F.; Balaguer Perez, F.A.;Huang, L; Tonra, J.R.; Lloyd, G.K.; Decherchi, S.; Díaz, J.F.; Steinmetz, M.O.; Cavalli, A. [2019]. Structure, Thermodynamics, and Kinetics of Plinabulin Binding to Two Tubulin Isotypes Chem 5,11, 2969-2986

Brindisi, M.; Ulivieri, C.; Alfano, G.; Gemma, S.; Balaguer, F.A.; Khan, T.; Grillo, A.; Chemi, G.; Menchon, G.; Prota, A.E.; Olieric, N.; Lucena-Agell, D.; Barasoain, I.; Diaz, J.F.; Nebbioso, A.; Conte, M.R.; Lopresti, L.; Magnano, S.; Amet, R.; Kinsella,P.; Zisterer, D.M.; Ibrahim, O.; O'Sullivan, J.; Morbidelli,L.; Spaccapelo, R.; Baldari, C.; Butini, S.; Novellino,E.; Campiani, G.; Altucci, L.; Steinmetz, M.O.; Brogi S. [2019]. Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents European Journal of Medicinal Chemistry 162 290-320

Bueno, O.; Gargantilla, M.; Estévez-Gallego, J.; Martins, S.; Díaz, J.F.; Camarasa, M.J.; Liekens,S.; Pérez‐Pérez, M.J.; Priego, E.M [2019]. Diphenyl ether derivatives occupy the expanded binding site of cyclohexanedione compounds at the colchicine site in tubulin by movement of the αT5 loop. European Journal of Medicinal Chemistry 171, 195-208

Cury, N. M.; Mühlethaler, T.; Brunelli, A.; Laranjeira, A.; Canevarolo, R.R; Zenatti, P.P.; Lucena-Agell, D. Barasoain, I.; Song, C.; Sun, D., Dovat,S; Yunes, R.A.; Prota, A.E. Steinmetz,, M.O.; Díaz, J.F.; Yunes, J.A. [2019]. Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia. iScience 21, 95–109

Unterhauser, K.; Pöltl, L.; Schneditz, G.; Kienesberger, S.; Glabonjat, R.A.; Kitsera, M.; Pletz, J.; Josa-Prado, F.; Dornisch, E.; Lembacher-Fadum, C.; Roier, S.; Gorkiewicze, G.; Lucena, D.; Barasoain,I.; Kroutil, W.; Wiedner, M.; Loizou, J.I.; Breinbauere, R.; Díaz, J.F.; Schilda, S.; Högenauer, C.; Zechner, E.L [2019]. Klebsiella oxytoca enterotoxins tilimycin and tilivallinehave distinct host DNA-damaging and microtubule stabilizing activities PNAS 116 (9) 3774-3783

Bravo-Plaza, I.; Hernández-González, M.; Pinar, M.; Díaz, J.F.; Peñalva, M.A. [2019]. Identification of the guanine nucleotide exchange factor for SAR1 in the filamentous fungal model Aspergillus nidulans. Biochimica et Biophysica Acta - Molecular Cell Research 1866, 118551

Alcolea, P.J.; Alonso, A.; Molina, R.; Jiménez, M.; Myler, P.J.; Larraga, V. [2019]. Functional genomics in sand fly-derived Leishmania promastigotes. PLoS Negl Trop Dis. (2019) 13(5): e0007288. doi: 10.1371/journal.pntd.0007288.

Alcolea, P.J.; Alonso, A.; Esteban, A.; Peris, P.; Cortés, A.; Castillo, J.A.; Larraga, V. [2019]. IL12 p35 and p40 subunit genes administered as pPAL plasmid constructs do not improve protection of pPAL-LACK vaccine against canine leishmaniasis. Plos One (2019) 22;14(2):e0212136 https://doi.org/10.1371/journal.pone.0212136

Sánchez-Carranza, J.N.; Díaz,J.F.; Redondo-Horcajo, M.; Barasoain, I.; Alvarez, L.; Lastres, P.; Romero-Estrada, A.; Aller, P.; González-Maya, L. [2018]. Gallic acid sensitizes paclitaxel-resistant human ovarian carcinoma cells through an increase in reactive oxygen species and subsequent downregulation of ERK activation. (2018) Oncology Reports DOI: 10.3892/or.2018.6382

Clara‐Rahola, J.; Casado‐Rodríguez, M.A,; Arrabal‐Campos, F. M.; Algarra, M.; López‐Romero, J.M.; Laurenti, M.; Fernández, I. Diaz, J.F.; , Rubio‐Retama, J.; Contreras‐Cáceres, R [2018]. Synthesis, Characterization and Application of pH responsive Au@p4VP microgels as platform for Selective SERS Analysis. (2018) J. Colloid Interface Sci. 514, 704–714

Bueno, O.; Estévez-Gallego, J.; Martins, S.; Prota, A.E.; Gago, F.; Gómez SanJuan, A.; Camarasa, M.J.; Barasoain, I.; Steinmetz, M.O.; Díaz, J.F.; Pérez-Pérez, M.J.; Liekens, S.; Priego, E.M. . High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design. (2018) Scientific Reports. 8, 4242

Field, J.J.; Pera, B.; Estévez-Gallego, J.; Calvo, E.; Rodríguez-Salarichs, J.; Sáez-Calvo, G.; Zuwerra, D.; Jordi, M.; Andreu, J.M.; Prota, A.E.; Ménchon, G.; Miller, J.H.; Altmann; K.H.; Díaz, J.F. [2018]. Zampanolide binding to tubulin indicates crosstalk of taxane site with colchicine and nucleotide sites. J. Nat. Prod. (2018) 81, 3, 494-505

Bueno, O.; Tobajas, G.; Quesada, E.; Estévez-Gallego, J.; Camarasa, M.J.; Díaz, J.F.; Liekens, S.; Priego, E.M.; Pérez-Pérez, M.J. . Conformational mimetics of the α-methyl chalcone TUB091 binding tubulin: Design, synthesis and antiproliferative activity. (2018) European Journal of Medicinal Chemistry. 148 337-348

Menchon, G.; Prota, A.E.; Lucena-Agell, D.; Bucher, P.; Jansen, R.; Irschik, H.; Mueller, R.; Paterson, I.; Diaz, J. F.; Altmann, K.H.; Steinmetz, M.O [2018]. A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin. (2018) NATURE COMMUNICATIONS. 9, 2016.

Alcolea, P.J.; Alonso, A.; Larraga, V. [2018]. The antibiotic resistance-free mammalian expression plasmid vctorpPal for development of three generation vaccines. Plasmid, 101:35-42. doi: 10.1016/j.plasmid.2018.12.002

Huecas, S.; Ramírez-Aportela, E.; Vergoñós, A.; Núñez-Ramírez, R.; Llorca, O. Díaz, David; J.F.; Juan-Rodríguez, D.; Oliva, M.A.; Castellen, P.; Andreu, J.M [2017]. Self-Organization of FtsZ Polymers in Solution Reveals Spacer Role of the Disordered C-Terminal Tail. Biophysical Journal 113, 1831–1844

Gilson, P., Josa-Prado, F., Beauvineau, C., Naud-Martin, D., Vanwonterghem, L., Mahuteau-Betzer, F., Moreno, A., Falson, P., Lafanechère, L., Frachet, V., Coll, J.-L., Fernando Díaz, J., Hurbin, A., Busser, B. [2017]. Identification of pyrrolopyrimidine derivative PP-13 as a novel microtubule-destabilizing agent with promising anticancer properties. Scientific Reports. 7: Article number 10209

Canela, M.-D., Noppen, S., Bueno, O., Prota, A.E., Bargsten, K., Sáez-Calvo, G., Jimeno, M.-L., Benkheil, M., Ribatti, D., Velázquez, S., Camarasa, M.-J., Fernando Díaz, J., Steinmetz, M.O., Priego, E.-M., Pérez-Pérez, M.-J., Liekens, S. [2017]. Antivascular and antitumor properties of the tubulin-binding chalcone TUB091. Oncotarget. 8:14325-14342.