Publications | Centro de Investigaciones Biológicas Margarita Salas - CIB Margarita Salas

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Ferreras-Gutiérrez M, Chaves-Arquero B, González-Magaña M, Merino N, Amusategui-Mateu I, Huecas S, Medrano FJ, Blanco FJ [2023]. Structural analysis of ING3 protein and histone H3 binding. Int J Biol Macromol (124724).

Laura Rubio-Pérez, Rodrigo Lázaro-Gorines, Seandean L. Harwood, Marta Compte, Rocío Navarro, Antonio Tapia-Galisteo, Jaume Bonet, Belén Blanco, Simon Lykkemark, Ángel Ramírez-Fernández, Mariola Ferreras-Gutiérrez, Carmen Domínguez-Alonso, Laura Díez-Alonso, Alejandro Segura-Tudela, Oana Hangiu, Ainhoa Erce-Llamazares, Francisco J. Blanco, Cruz Santos, José L. Rodríguez-Peralto, Laura Sanz & Luis Álvarez-Vallina. [2023]. A PD-L1/EGFR bispecific antibody combines immune checkpoint blockade and direct anti-cancer action for an enhanced anti-tumor response. OncoImmunology 12,1.

Jingyi Zhao, Vincent DiGiacomo, Mariola Ferreras-Gutierrez, Shiva Dastjerdi, Alain Ibáñez de Opakua, Jong-Chan Park, Alex Luebbers, Qingyan Chen, Aaron Beeler, Francisco J. Blanco, and Mikel Garcia-Marcos. [2023]. Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer. PNAS 120 (18) e2213140120.

Liu J, Chaves-Arquero B, Wei P, Tencer AH, Ruiz-Albor A, Zhang G, Blanco FJ, Kutateladze TG [2023]. Molecular insight into the PCNA-binding mode of FBH1. Structure 31, 1-7.

Cano A, Vazquez-Chantada M, Conde-Vancells J, Gonzalez-Lahera A, Mosen-Ansorena D, Blanco FJ, Clément K, Aron-Wisnewsky J, Tran A, Gual P, García-Monzón C, Caballería J, Castro A, Martínez-Chantar ML, Mato JM, Zhu H, Finnell RH, Aransay AM [2023]. Impaired Function of Solute Carrier Family 19 Leads to Low Folate Levels and Lipid Droplet Accumulation in Hepatocytes. Biomedicines 11(2), 337.

O Hangiu, M Compte, A Dinesen, R Navarro, A Tapia-Galisteo, OA Mandrup, A Erce-Llamazares, R Lázaro-Gorines, D Nehme-Álvarez, C Domínguez-Alonso, SL Harwood, C Alfonso, B Blanco, L Rubio-Pérez, A Jiménez-Reinoso, L Díez-Alonso, FJ Blanco, L Sanz, KA Howard, L Álvarez-Vallina [2022]. A tumor target-dependent 4-1BB agonist antibody fused to albumin engineered for enhanced FcRn binding induces anti-tumor immunity without toxicity. iScience 25, 104958.

B Chaves-Arquero, C Persson, N Merino, J Tomás-Cortazar, AL Rojas, J Anguita, FJ Blanco [2022]. Structural Analysis of the Black-Legged Tick Saliva Protein Salp15. International Journal of Molecular Sciences. 23, 3134.

Tapia-Galisteo A, Sánchez Rodríguez Í, Aguilar-Sopeña O, Harwood SL, Narbona J, Ferreras Gutierrez M, Navarro R, Martín-García L, Corbacho C, Compte M, Lacadena J, Blanco FJ, Chames P, Roda-Navarro P, Álvarez-Vallina L, Sanz L [2022]. Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer. OncoImmunology. 11:2034355.

Compte M, Harwood SL, Erce-Llamazares A, Tapia-Galisteo A, Romero E, Ferrer I, Garrido-Martin EM, Enguita AB, Ochoa MC, Blanco B, Oteo M, Merino N, Nehme-Álvarez D, Hangiu O, Domínguez-Alonso C, Zonca M, Ramírez-Fernández A, Blanco FJ, Morcillo MA, Muñoz IG, Melero I, Rodriguez-Peralto JL, Paz-Ares L, Sanz L, Alvarez-Vallina L [2021]. An Fc-free EGFR-specific 4-1BB-agonistic Trimerbody Displays Broad Antitumor Activity in Humanized Murine Cancer Models without Toxicity. Clin Cancer Res 27, 3167-3177.

Romero JA, Nawrocka EK, Shchukina A, Blanco FJ, Diercks T, Kazimierczuk K [2020]. Non‐Stationary Complementary Non‐Uniform Sampling (NOSCO NUS) for Fast Acquisition of Serial 2D NMR Titration Data. Angew Chem Int Ed Engl 132, 23702.

Bruzzone C, Loizaga-Iriarte A, Sánchez-Mosquera P, Gil-Redondo R, Astobiza I, Diercks T, Cortazar AR, Ugalde-Olano A, Schäfer H, Blanco FJ, Unda M, Cannet C, Spraul M, Mato JM, Embade N, Carracedo A, Millet O. [2020]. 1H NMR-Based Urine Metabolomics Reveals Signs of Enhanced Carbon and Nitrogen Recycling in Prostate Cancer. J Proteome Res 19, 2419-2428.

González-Magaña A, Blanco FJ. [2020]. Human PCNA Structure, Function and Interactions. Biomolecules 10, 570

Lancey C, Tehseen M, Raducanu VS, Rashid F, Merino N, Ragan TJ, Savva CG, Zaher MS, Shirbini A, Blanco FJ, Hamdan SM, De Biasio A. [2020]. Structure of the processive human Pol δ holoenzyme. Nature Commun 11, 1109

Palacios A, Blanco FJ [2020]. Macromolecular crowding increases the affinity of the PHD of ING4 for the histone H3K4me3 mark. Biomolecules 10, 234

González-Magaña A, de Opakua AI, Merino N, Monteiro H, Diercks T, Murciano-Calles J, Luque I, Bernadó P, Cordeiro TN, Biasio A, Blanco FJ. [2019]. Double Monoubiquitination Modifies the Molecular Recognition Properties of p15(PAF) Promoting Binding to the Reader Module of Dnmt1. ACS Chem Biol 14, 2315-2326.

Ormaza G, Rodríguez JA, de Opakua AI, Merino N, Villate M, Gorroño I, Rábano M, Palmero I, Vilaseca M, Kypta R, Vivanco MD, Rojas AL, Blanco FJ [2019]. The tumor suppressor ING5 is a dimeric, bivalent recognition molecule of the H3K4me3 mark. J Mol Biol 431, 2298-2319

Compte M, Harwood SL, Muñoz IG, Navarro R, Zonca M, Perez-Chacon G,Erce-Llamazares A, Merino N, Tapia-Galisteo A, Cuesta AM, Mikkelsen K, Caleiras E, Nuñez-Prado N, Aznar MA, Lykkemark S, Martínez-Torrecuadrada J, Melero I, Blanco FJ, Bernardino de la Serna J, Zapata JM, Sanz L, Alvarez-Vallina L [2018]. A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity. Nature Commun 9, 4809

A de Biasio, A Ibáñez de Opakua, MJ Bostok, D Nietlispach, T Diercks, FJ Blanco [2018]. A generalized approach for NMR studies of lipid-protein interactions based on sparse fluorination of acyl chains. Chem Comm 54, 7306-7309.

A Ibáñez de Opakua, K Parag-Sharma, V DiGiacomo, N Merino, A Leyme, A Marivin, M Villate, LT Nguyen, MA de la Cruz-Morcillo, JB Blanco-Canosa, S Ramachandran, George S Baillie, RA Cerione, FJ Blanco, M Garcia-Marcos [2017]. Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif. Nature Commun 8, 15163.

De Biasio A, Ibáñez de Opakua A, Mortuza GB, Molina R, Cordeiro TN, Castillo F, Villate M, Merino N, Delgado S, Gil-Cartón D, Luque I, Diercks T, Bernadó P, Montoya G, Blanco FJ. [2015]. Structure of the p15PAF-PCNA complex and implications for clamp sliding on the DNA during replication and repair. Nature Commun 6, 6439.