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Laura Rubio-Pérez, Rodrigo Lázaro-Gorines, Seandean L. Harwood, Marta Compte, Rocío Navarro, Antonio Tapia-Galisteo, Jaume Bonet, Belén Blanco, Simon Lykkemark, Ángel Ramírez-Fernández, Mariola Ferreras-Gutiérrez, Carmen Domínguez-Alonso, Laura Díez-Alonso, Alejandro Segura-Tudela, Oana Hangiu, Ainhoa Erce-Llamazares, Francisco J. Blanco, Cruz Santos, José L. Rodríguez-Peralto, Laura Sanz & Luis Álvarez-Vallina.
[2023]. A PD-L1/EGFR bispecific antibody combines immune checkpoint blockade and direct anti-cancer action for an enhanced anti-tumor response. OncoImmunology 12,1.
Jingyi Zhao, Vincent DiGiacomo, Mariola Ferreras-Gutierrez, Shiva Dastjerdi, Alain Ibáñez de Opakua, Jong-Chan Park, Alex Luebbers, Qingyan Chen, Aaron Beeler, Francisco J. Blanco, and Mikel Garcia-Marcos.
[2023]. Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer. PNAS 120 (18) e2213140120.
Cano A, Vazquez-Chantada M, Conde-Vancells J, Gonzalez-Lahera A, Mosen-Ansorena D, Blanco FJ, Clément K, Aron-Wisnewsky J, Tran A, Gual P, García-Monzón C, Caballería J, Castro A, Martínez-Chantar ML, Mato JM, Zhu H, Finnell RH, Aransay AM
[2023]. Impaired Function of Solute Carrier Family 19 Leads to Low Folate Levels and Lipid Droplet Accumulation in Hepatocytes. Biomedicines 11(2), 337.
O Hangiu, M Compte, A Dinesen, R Navarro, A Tapia-Galisteo, OA Mandrup, A Erce-Llamazares, R Lázaro-Gorines, D Nehme-Álvarez, C Domínguez-Alonso, SL Harwood, C Alfonso, B Blanco, L Rubio-Pérez, A Jiménez-Reinoso, L Díez-Alonso, FJ Blanco, L Sanz, KA Howard, L Álvarez-Vallina
[2022]. A tumor target-dependent 4-1BB agonist antibody fused to albumin engineered for enhanced FcRn binding induces anti-tumor immunity without toxicity. iScience 25, 104958.
Tapia-Galisteo A, Sánchez Rodríguez Í, Aguilar-Sopeña O, Harwood SL, Narbona J, Ferreras Gutierrez M, Navarro R, Martín-García L, Corbacho C, Compte M, Lacadena J, Blanco FJ, Chames P, Roda-Navarro P, Álvarez-Vallina L, Sanz L
[2022]. Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer. OncoImmunology. 11:2034355.
Compte M, Harwood SL, Erce-Llamazares A, Tapia-Galisteo A, Romero E, Ferrer I, Garrido-Martin EM, Enguita AB, Ochoa MC, Blanco B, Oteo M, Merino N, Nehme-Álvarez D, Hangiu O, Domínguez-Alonso C, Zonca M, Ramírez-Fernández A, Blanco FJ, Morcillo MA, Muñoz IG, Melero I, Rodriguez-Peralto JL, Paz-Ares L, Sanz L, Alvarez-Vallina L
[2021]. An Fc-free EGFR-specific 4-1BB-agonistic Trimerbody Displays Broad Antitumor Activity in Humanized Murine Cancer Models without Toxicity. Clin Cancer Res 27, 3167-3177.
Bruzzone C, Loizaga-Iriarte A, Sánchez-Mosquera P, Gil-Redondo R, Astobiza I, Diercks T, Cortazar AR, Ugalde-Olano A, Schäfer H, Blanco FJ, Unda M, Cannet C, Spraul M, Mato JM, Embade N, Carracedo A, Millet O.
[2020]. 1H NMR-Based Urine Metabolomics Reveals Signs of Enhanced Carbon and Nitrogen Recycling in Prostate Cancer. J Proteome Res 19, 2419-2428.
Lancey C, Tehseen M, Raducanu VS, Rashid F, Merino N, Ragan TJ, Savva CG, Zaher MS, Shirbini A, Blanco FJ, Hamdan SM, De Biasio A.
[2020]. Structure of the processive human Pol δ holoenzyme. Nature Commun 11, 1109
González-Magaña A, de Opakua AI, Merino N, Monteiro H, Diercks T, Murciano-Calles J, Luque I, Bernadó P, Cordeiro TN, Biasio A, Blanco FJ.
[2019]. Double Monoubiquitination Modifies the Molecular Recognition Properties of p15(PAF) Promoting Binding to the Reader Module of Dnmt1. ACS Chem Biol 14, 2315-2326.
Ormaza G, Rodríguez JA, de Opakua AI, Merino N, Villate M, Gorroño I, Rábano M, Palmero I, Vilaseca M, Kypta R, Vivanco MD, Rojas AL, Blanco FJ
[2019]. The tumor suppressor ING5 is a dimeric, bivalent recognition molecule of the H3K4me3 mark. J Mol Biol 431, 2298-2319
Compte M, Harwood SL, Muñoz IG, Navarro R, Zonca M, Perez-Chacon G,Erce-Llamazares A, Merino N, Tapia-Galisteo A, Cuesta AM, Mikkelsen K, Caleiras E, Nuñez-Prado N, Aznar MA, Lykkemark S, Martínez-Torrecuadrada J, Melero I, Blanco FJ, Bernardino de la Serna J, Zapata JM, Sanz L, Alvarez-Vallina L
[2018]. A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity. Nature Commun 9, 4809
A Ibáñez de Opakua, K Parag-Sharma, V DiGiacomo, N Merino, A Leyme, A Marivin, M Villate, LT Nguyen, MA de la Cruz-Morcillo, JB Blanco-Canosa, S Ramachandran, George S Baillie, RA Cerione, FJ Blanco*, M Garcia-Marcos*
[2017]. Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif. Nature Commun 8, 15163.
De Biasio A, Ibáñez de Opakua A, Mortuza GB, Molina R, Cordeiro TN, Castillo F, Villate M, Merino N, Delgado S, Gil-Cartón D, Luque I, Diercks T, Bernadó P, Montoya G, Blanco FJ.
[2015]. Structure of the p15PAF-PCNA complex and implications for clamp sliding on the DNA during replication and repair. Nature Commun 6, 6439.