Mantoani, S.P. ; Perez-Cantuaria, T.; Vilela, A.F.L.; Cardoso, C.L.; Martínez, A.; Carvalho I.
[2016]. Novel Triazole-quinoline Derivatives as Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer Treatment. Molecules, 21:193
Cheng, Y.; Pardo, M.; de Souza-Armini, R.; Martinez, A.; Moushine, H.; Zagury, J.F.; Jope, R.S.; Beurel E.
[2016]. Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior. Brain, Behav., Immun. pii: S0889-1591(15)30074-X
Concetta Di Martino, R.M.; De Simone, A.; Andrisano, V.; Bisignano, P.; Bisi, A.; Gobbi, S.; Rampa, A.; Perez, D.I.; Martinez, A.; Bottegoni, G.; Cavalli, A.; Belluti, F.
[2016]. The versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors. J. Med. Chem. 2016, 59, 531-544.
Garcia, A. M.; Martinez, A.; Gil, C.
[2016]. Enhancing cAMP levels as strategy for the treatment of neuropsychiatric disorders. Curr. Top. Med. Chem. 2016, 16, 3527-3535
de Munck García, E.; Palomo, V.; Muñoz-Sáez, E.; Perez, D. I.; Gómez Miguel, B.; Solas, M. T.; Gil, C.; Martinez, A.; Arahuetes Portero, R. M.
[2016]. Small GSK-3 inhibitor shows efficacy in a motor neuron disease murine model modulating autophagy. PlosOne. 2016, 11, e01627232.
Morales-Garcia, J. A.; Aguilar-Morante, D.; Hernandez-Encinas, E.; Alonso-Gil, S.; Gil, C.; Martinez, A.; Santos, A.; Perez-Castillo, A.
[2015]. Silencing Phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice. Neurobiol. Aging 2015, 36, 1160-1173
Sastre, A.; Campillo, N. E.; Gil, C.; Martinez, A.
[2015]. Therapeutic approaches for the future treatment of Fragile X. Curr. Opin. Behav. Sci. 2015, 4, 6-21
Silva, T.; Bravo, J.; Summavielle, T.; Remião, F.; Perez, C.; Gil, C.; Martinez, A.; Borges, F.
[2015]. Biology-oriented development of novel lipophilic antioxidants with neuroprotective activity. RSC Adv. 2015, 5, 15800-15811.
Prati, F.; De Simone, A.; Armirotti, A.; Summa, M.; Pizzirani, D.; Scarpelli, R.; Mandru, S.; Bertozzi, P.; Perez, D. I.; Andrisano, V.; Perez-Castillo, A.; Monti, B.; Massenzio, F.; Polito, L.; Racchi, M.; Sabatino, P.; Bottegoni, G.; Martinez, A.; Cavalli, A.; Bolognesi, M. L.
[2015]. Triazinones as the first dual BACE-1/GSK-3β fragment hits against Alzheimer’s disease. ACS Chem. Neurosci., 2015, 6, 1665-1682
de Munck, E.; Muñoz-Saez, E.; Miguel, B. G.; Solas, M. T.; Martinez, A.; Arahuetes, R. M.
[2015]. Morphometric and neurochemical alterations found in L-BMAA treated rats. Environ. Tox. Pharmacol., 2015, 39, 1232-1245.
Pardo, M.; King, M. K.; Perez-Costas, E.; Melendez-Ferro, M.; Martinez, A.; Beurel, E.; Jope, R. S.
[2015]. Impairments in cognition and neural precursor cell proliferation in mice expressing constitutively active glycogen synthase kinase 3. Front. Behavior. Neurosci. 2015, vol 9, article 55. doi: 10.3389/fnbeh.2015.00055.
de Munck, E.; Arahuetes, R. M.; Martinez, A.; Solas, M. T.; Miguel, B. M.
[2015]. Analysis of β-N-methylamino-L-alanine (L-BMAA) neurotoxicity over rat cerebellum. NeuroToxicology, 2015, 48, 192-205.
Prati, F.; de Simone, A.; Bisignano, P.; Armirotti, A.; Summa, M.; Pizzirani, D.; Scarpelli, R.; Andrisano, V.; Perez-Castillo, A.; Monti, B.; Massenzio, F.; Polito, L.; Racchi, M.; Favia, A. D.; Bottegoni, G.; Martinez, A.; Bolognessi, M. L.; Cavalli, A.
[2015]. Multitarget drug discovery for Alzheimer’s disease; triazinones as the first dual BACE1/GSK-3β fragment hits Angew. Chem. Int. Ed. Engl. 2015, 54, 1578-1582.
Mestre, L.; Morales-García, J. A.; Redondo, M.; Perez, C.; Alonso-Gil, S.; Perez-Castillo, A.; Gil, C.; Martinez, A.; Guaza, C.
[2015]. Inhibitors of phosphodiesterase-7 as novel drugs for treatment of multiple sclerosis Br. J. Pharmacol. 2015, 172, 4277-4290
Morales-García, J. A.; Alonso-Gil, S.; Gil, C.; Martínez, A.; Santos, A.; Perez-Castillo, A.
[2015]. Phosphodiesterase 7 inhibition induces dopaminergic neurogenesis in hemiparkinsonian rats. Stem Cells Transl. Med. 2015, 4, 565-574.
Pérez, C.; Ruiz del Castillo, M. L.; Gil, C.; Blanch, G. P.; Flores, G.
[2015]. Supercritical Fluid Extraction of grape seeds: Extract chemical composition, antioxidant activity and inhibition of nitrite production in LPS-stimulated Raw 264.7 cell. Food Funct. 2015, 6, 2607-2613
García, A. M.; Jung, N.; Gil, C.; Nieger, M.; Bräse, S.
[2015]. Solid phase synthesis of functionalized indazoles using triazenes – Scope and limitations. RSC Adv. 2015, 5, 65540-65545
Pérez, D. I.; Martinez, A.; Gil, C.; Campillo, N. E.
[2015]. From bitopic inhibitors to multitarget drugs for Alzheimer’s disease future treatment. Curr. Med. Chem. 2015, 22, 3789-3806
Cahlíková, L.; Pérez, D.I.; Štěpánková, Š.; Chlebek, J.; Šafratová, M.; Hošt'álková, A.; Opletal, L.
[2015]. In vitro inhibitory effects of 8-O-demethylmaritidine and undulatine on acetylcholinesterase and their predicted penetration across the blood-brain barrier. J. Nat. Prod. 2015, 78,1189-1192
Moreira, D. N.; Fresno, N.; Pérez-Fernández, R.; Frizzo, C. P.; Goya, P.; Marco, C.; Martins, M. a. P.; Elguero, J.
[2015]. Brønsted acid–base pairs of drugs as dual ionic liquids: NMR ionicity studies. Tetrahedron 2015, 71, 676-685
