Publications | Centro de Investigaciones Biológicas Margarita Salas

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**Guzmán-Benito I, Robinson C, Hua C, Sede A, Elvira-González L, Punzón I, Heinlein M, Nürnberger T, LLAVE C*. [2023].** The receptor-like kinase BIR1 inhibits elicitor-induced plasmodesmata callose deposition and PTI gene expression and requires EDS1 and SOBIR1 to cause dose-dependent cell-death in Arabidopsis. BioRxiv doi:10.1101/2023.06.23.546234

**Pitzalis N , Amari K , Graindorge S, Pflieger D , Donaire L, Wassenegger M, Llave C, M. Heinlein [2020].** Turnip mosaic virus in oilseed rape activates networks of sRNA-mediated interactions between viral and host genomes. Communications Biology doi: 10.1038/s42003-020-01427-y

**Guzmán-Benito I, Donaire L, Amorim-Silva V, Vallarino JG, Esteban A, Wierzbicki AT, Ruiz-Ferrer V, Llave C* [2019].** The immune repressor BIR1 contributes to antiviral defense and undergoes transcriptional and post-transcriptional regulation during viral infections. New Phytologist 224: 421-438. doi: 10.1111/nph.15931. [Epub ahead of print]

**Diezma-Navas L, Pérez-González A, Artaza H, Alonso L, Caro E, Llave C, Ruiz-Ferrer V [2019].** Crosstalk between epigenetic silencing and infection by Tobacco rattle virus in Arabidopsis. Molecular Plant Pathology 20: 1439-1452. DOI: 10.1111/mpp.12850

**Donaire L, Llave C* [2019].** Computational Workflow for Small RNA Profiling in Virus-Infected Plants. Methods Mol Biol. 2019;2028:185-214. doi: 10.1007/978-1-4939-9635-3_11.

Llave C [2016]. Dynamic cross-talk between host primary metabolism and viruses during infections in plants. Current Opinion in Virology 19, 50-55. doi: 10.1016/j.coviro.2016.06.013

**Fernández-Calvino L, Martínez-Priego L, Szabo EZ, Guzmán-Benito I, González I, Canto T, Lakatos L, Llave C* [2016].** Tobacco rattle virus 16K silencing suppressor binds AGO4 and inhibits formation of RNA silencing complexes. Journal of General Virology 97(1):246-57. doi: 10.1099/jgv.0.000323.

**Fernández-Calvino L, Guzmán-Benito I, Del Toro FJ, Donaire L, Castro-Sanz AB, Ruíz-Ferrer V, Llave C* [2016].** Activation of senescence-associated dark-inducible genes during infection contributes to enhance susceptibility to plant viruses. Molecular Plant Pathololy 17(1):3-15. doi: 10.1111/mpp.12257.

**Fernández-Calvino L, Osorio S, Hernández ML, Hamada IB, Del Toro FJ, Donaire L, Yu A, Bustos R, Fernie AR, Martínez-Rivas JM and Llave C* [2014].** Virus-Induced Alterations in Primary Metabolism Modulate Susceptibility to Tobacco rattle virus in Arabidopsis. Plant Physiology 166(4):1821-38. doi: 10.1104/pp.114.250340.

Campo S, Peris-Peris C, Siré C, Moreno AB, Donaire L, Zytnicki M, Notredame C, Llave C and San Segundo B [2013]. Identification of a novel microRNA (miRNA) from rice that targets an alternatively spliced transcript of the Nramp6 (Natural resistance-associated macrophage protein 6) gene involved in pathogen resistance. New Phytologist 199(1):212-27. doi: 10.1111/nph.

Rodrigo G, Carrera J, Ruiz-Ferrer V, del Toro FJ, Llave C, Voinnet O, Elena SF [2012]. A meta-analysis reveals the commonalities and differences in Arabidopsis thaliana response to different viral pathogens. PLoS One 7(7):e40526. doi: 10.1371/journal.pone.0040526.

Csukasi F, Donaire L, Casañal A, Martínez-Priego L, Botella MA, Medina-Escobar N, Llave C, Valpuesta V. [2012]. Two strawberry miR159 family members display developmental-specific expression patterns in the fruit receptacle and cooperatively regulate Fa-GAMYB. New Phytologist 195(1):47-57. doi: 10.1111/j.1469-8137.2012.04134.x.

**Donaire L, Pedrola L, Rosa Rde L, Llave C* [2011].** High-throughput sequencing of RNA silencing-associated small RNAs in olive (Olea europaea L.). PLoS One 6(11):e27916. doi: 10.1371/journal.pone.0027916.

Gonzalez-Ibeas D, Blanca J, Donaire L, Saladié M, Mascarell-Creus A, Cano-Delgado A, Garcia-Mas J, Llave C, Aranda MA. [2011]. Analysis of the melon (Cucumis melo) small RNAome by high-throughput pyrosequencing. BMC Genomics 12:393. doi: 10.1186/1471-2164-12-393.

Martínez G, Forment J, Llave C, Pallás V, Gómez G. [2011]. High-throughput sequencing, characterization and detection of new and conserved cucumber miRNAs. PLoS One 6(5):e19523. doi: 10.1371/journal.pone.0019523.

**Llave C*, Franco-Zorrilla JM, Solano R, Barajas D. [2011].** Target validation of plant microRNAs. Methods Mol Biol. 732:187-208.

Llave C. [2010]. Virus-derived small interfering RNAs at the core of plant-virus interactions. Trends Plant Science 15(12):701-7. doi: 10.1016/j.tplants.2010.09.001.

Martinez G, Donaire L, Llave C, Pallas V, Gomez G. [2010]. High-throughput sequencing of Hop stunt viroid-derived small RNAs from cucumber leaves and phloem. Mol Plant Pathol. 11(3):347-59.

**Donaire L, Wang Y, Gonzalez-Ibeas D, Mayer KF, Aranda MA, Llave C* [2009].** Deep-sequencing of plant viral small RNAs reveals effective and widespread targeting of viral genomes. Virology 392(2):203-14

Franco-Zorrilla JM, Del Toro FJ, Godoy M, Pérez-Pérez J, López-Vidriero I, Oliveros JC, García-Casado G, Llave C, Solano R. [2009]. Genome-wide identification of small RNA targets based on target enrichment and microarray hybridizations. Plant J. 59(5):840-50

Pitzalis N , Amari K , Graindorge S, Pflieger D , Donaire L, Wassenegger M, Llave C*, M. Heinlein* [2020]. Turnip mosaic virus in oilseed rape activates networks of sRNA-mediated interactions between viral and host genomes. Communications Biology doi: 10.1038/s42003-020-01427-y

Diezma-Navas L, Pérez-González A, Artaza H, Alonso L, Caro E, Llave C*, Ruiz-Ferrer V* [2019]. Crosstalk between epigenetic silencing and infection by Tobacco rattle virus in Arabidopsis. Molecular Plant Pathology 20: 1439-1452. DOI: 10.1111/mpp.12850

Donaire L, Llave C* [2019]. Computational Workflow for Small RNA Profiling in Virus-Infected Plants. Methods Mol Biol. 2019;2028:185-214. doi: 10.1007/978-1-4939-9635-3_11.

Llave C [2016]. Dynamic cross-talk between host primary metabolism and viruses during infections in plants. Current Opinion in Virology 19, 50-55. doi: 10.1016/j.coviro.2016.06.013

Fernández-Calvino L, Martínez-Priego L, Szabo EZ, Guzmán-Benito I, González I, Canto T, Lakatos L, Llave C* [2016]. Tobacco rattle virus 16K silencing suppressor binds AGO4 and inhibits formation of RNA silencing complexes. Journal of General Virology 97(1):246-57. doi: 10.1099/jgv.0.000323.

Rodrigo G, Carrera J, Ruiz-Ferrer V, del Toro FJ, Llave C, Voinnet O, Elena SF [2012]. A meta-analysis reveals the commonalities and differences in Arabidopsis thaliana response to different viral pathogens. PLoS One 7(7):e40526. doi: 10.1371/journal.pone.0040526.

Donaire L, Pedrola L, Rosa Rde L, Llave C* [2011]. High-throughput sequencing of RNA silencing-associated small RNAs in olive (Olea europaea L.). PLoS One 6(11):e27916. doi: 10.1371/journal.pone.0027916.

Gonzalez-Ibeas D, Blanca J, Donaire L, Saladié M, Mascarell-Creus A, Cano-Delgado A, Garcia-Mas J, Llave C, Aranda MA. [2011]. Analysis of the melon (Cucumis melo) small RNAome by high-throughput pyrosequencing. BMC Genomics 12:393. doi: 10.1186/1471-2164-12-393.

Martínez G, Forment J, Llave C, Pallás V, Gómez G. [2011]. High-throughput sequencing, characterization and detection of new and conserved cucumber miRNAs. PLoS One 6(5):e19523. doi: 10.1371/journal.pone.0019523.

Llave C*, Franco-Zorrilla JM, Solano R, Barajas D. [2011]. Target validation of plant microRNAs. Methods Mol Biol. 732:187-208.

Llave C. [2010]. Virus-derived small interfering RNAs at the core of plant-virus interactions. Trends Plant Science 15(12):701-7. doi: 10.1016/j.tplants.2010.09.001.

Martinez G, Donaire L, Llave C, Pallas V, Gomez G. [2010]. High-throughput sequencing of Hop stunt viroid-derived small RNAs from cucumber leaves and phloem. Mol Plant Pathol. 11(3):347-59.

Donaire L, Wang Y, Gonzalez-Ibeas D, Mayer KF, Aranda MA, Llave C* [2009]. Deep-sequencing of plant viral small RNAs reveals effective and widespread targeting of viral genomes. Virology 392(2):203-14

Franco-Zorrilla JM, Del Toro FJ, Godoy M, Pérez-Pérez J, López-Vidriero I, Oliveros JC, García-Casado G, Llave C, Solano R. [2009]. Genome-wide identification of small RNA targets based on target enrichment and microarray hybridizations. Plant J. 59(5):840-50

**Pitzalis N , Amari K , Graindorge S, Pflieger D , Donaire L, Wassenegger M, Llave C, M. Heinlein [2020].** Turnip mosaic virus in oilseed rape activates networks of sRNA-mediated interactions between viral and host genomes. Communications Biology doi: 10.1038/s42003-020-01427-y

**Diezma-Navas L, Pérez-González A, Artaza H, Alonso L, Caro E, Llave C, Ruiz-Ferrer V [2019].** Crosstalk between epigenetic silencing and infection by Tobacco rattle virus in Arabidopsis. Molecular Plant Pathology 20: 1439-1452. DOI: 10.1111/mpp.12850

**Donaire L, Llave C* [2019].** Computational Workflow for Small RNA Profiling in Virus-Infected Plants. Methods Mol Biol. 2019;2028:185-214. doi: 10.1007/978-1-4939-9635-3_11.

**Donaire L, Pedrola L, Rosa Rde L, Llave C* [2011].** High-throughput sequencing of RNA silencing-associated small RNAs in olive (Olea europaea L.). PLoS One 6(11):e27916. doi: 10.1371/journal.pone.0027916.

**Llave C*, Franco-Zorrilla JM, Solano R, Barajas D. [2011].** Target validation of plant microRNAs. Methods Mol Biol. 732:187-208.

**Donaire L, Wang Y, Gonzalez-Ibeas D, Mayer KF, Aranda MA, Llave C* [2009].** Deep-sequencing of plant viral small RNAs reveals effective and widespread targeting of viral genomes. Virology 392(2):203-14