Publications | Centro de Investigaciones Biológicas Margarita Salas - CIB Margarita Salas

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Prota A, Bargsten , Diaz JF, Marsh M , Cuevas, Liniger M, Neuhaus C, Andreu JM, Altmann CH, Steinmetz MO [2014]. A new tubulin binding site and pharmacophore for clinically relevant microtubule-destabilizing agents, Proc. Natl. Acad. Sci. USA 111,13817-13821. doi: 10.1073/pnas.1408124111d

Ramírez-Aportela, E., López-Blanco, J.R., Andreu, J.M., Chacón, P. [2014]. Understanding nucleotide-regulated FtsZ filament dynamics and the monomer assembly switch with large-scale atomistic simulations. Biophysical Journal. 107:2164-2176.

Pera, B., Barasoain, I., Pantazopoulou, A., Canales, A., Matesanz, R., Rodriguez-Salarichs, J., García-Fernandez, L.F., Moneo, V., Jiménez-Barbero, J., Galmarini, C.M., Cuevas, C., Peñalva, M.A., Díaz, J.F., Andreu, J.M. [2013]. New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanism. ACS Chemical Biology. 8:2084-2094.

Andreu, J.M., Oliva, M.A. [2013]. Purification and assembly of bacterial tubulin btuba/b and constructs bearing eukaryotic tubulin sequences. Methods in Cell Biology. 115:269-281.

Ruiz-Avila, L.B., Huecas, S., Artola, M., Vergoñós, A., Ramírez-Aportela, E., Cercenado, E., Barasoain, I., Vázquez-Villa, H., Martín-Fontecha, M., Chacón, P., López-Rodríguez, M.L., Andreu, J.M. [2013]. Synthetic inhibitors of bacterial cell division targeting the GTP-binding site of FtsZ. ACS Chemical Biology. 8:2072-2083.

Marcelo, F., Huecas, S., Ruiz-Ávila, L.B., Cañada, F.J., Perona, A., Poveda, A., Martín-Santamaría, S., Morreale, A., Jiménez-Barbero, J., Andreu, J.M. [2013]. Interactions of bacterial cell division protein FtsZ with C8-substituted guanine nucleotide inhibitors. A combined NMR, biochemical and molecular modeling perspective. Journal of the American Chemical Society. 135:16418-16428.

Álvarez, R., Puebla, P., Díaz, J.F., Bento, A.C., García-Navas, R., De La Iglesia-Vicente, J., Mollinedo, F., Andreu, J.M., Medarde, M., Peláez, R. [2013]. Endowing indole-based tubulin inhibitors with an anchor for derivatization: Highly potent 3-substituted indolephenstatins and indoleisocombretastatins. Journal of Medicinal Chemistry. 56:2813-2827.

Keffer, J.L., Huecas, S., Hammill, J.T., Wipf, P., Andreu, J.M., Bewley, C.A. [2013]. Chrysophaentins are competitive inhibitors of FtsZ and inhibit Z-ring formation in live bacteria. Bioorganic and Medicinal Chemistry. 21:5673-5678.

Abad, A., López-Pérez, J.L., Del Olmo, E., García-Fernández, L.F., Francesch, A., Trigili, C., Barasoain, I., Andreu, J.M., Fernand Díaz, J., San Feliciano, A. [2012]. Synthesis and antimitotic and tubulin interaction profiles of novel pinacol derivatives of podophyllotoxins. Journal of Medicinal Chemistry. 55:6724-6737.

Calvo, E., Barasoain, I., Matesanz, R., Pera, B., Camafeita, E., Pineda, O., Hamel, E., Vanderwal, C.D., Andreu, J.M., López, J.A., Díaz, J.F. [2012]. Cyclostreptin derivatives specifically target cellular tubulin and further map the paclitaxel site. Biochemistry. 51:329-341.

Pissuti Damalio, J.C., Garcia, W., Alves MacÊdo, J.N., De Almeida Marques, I., Andreu, J.M., Giraldo, R., Garratt, R.C., Ulian Araújo, A.P. [2012]. Self assembly of human septin 2 into amyloid filaments. Biochimie. 94:628-636.

Oliva, M.A., Martin-Galiano, A.J., Sakaguchi, Y., Andreu, J.M. [2012]. Tubulin homolog TubZ in a phage-encoded partition system. Proc. Natl. Acad. Sci. USA. 109:7711-7716.

Schaffner-Barbero, C., Martín-Fontecha, M., Chacón, P., Andreu, J.M. [2012]. Targeting the assembly of bacterial cell division protein FtsZ with small molecules. ACS Chemical Biology. 7:269-277.

de Almeida Marques, I., Valadares, N.F., Garcia, W., Damalio, J.C.P., Macedo, J.N.A., de Araújo, A.P.U., Botello, C.A., Andreu, J.M., Garratt, R.C. [2012]. Septin C-Terminal Domain Interactions: Implications for Filament Stability and Assembly. Cell Biochemistry and Biophysics. 62:317-328.

Matesanz, R., Rodríguez-Salarichs, J., Pera, B., Canales, A., Andreu, J.M., Jiménez-Barbero, J., Bras, W., Nogales, A., Fang, W.-S., Díaz, J.F. [2011]. Modulation of microtubule interprotofilament interactions by modified taxanes. Biophysical Journal. 101:2970-2980.

Canales, A., Rodríguez-Salarichs, J., Trigili, C., Nieto, L., Coderch, C., Andreu, J.M., Paterson, I., Jiménez-Barbero, J., Díaz, J.F. [2011]. Insights into the interaction of discodermolide and docetaxel with tubulin. Mapping the binding sites of microtubule-stabilizing agents by using an integrated NMR and computational approach. ACS Chemical Biology. 6:789-799.

Canales, A., Nieto, L., Rodríguez-Salarichs, J., Sánchez-Murcia, P.A., Coderch, C., Cortés-Cabrera, A., Paterson, I., Carlomagno, T., Gago, F., Andreu, J.M., Altmann, K.-H., Jiménez-Barbero, J., Díaz, J.F. [2014]. Molecular recognition of epothilones by microtubules and tubulin dimers revealed by biochemical and NMR approaches. ACS Chemical Biology. 9:1033-1043.

Schaffner-Barbero C, Martín-Fontecha M, Chacón P, Andreu, JM [2011]. Targetting assembly of cell division protein FtsZ with small molecules (Review) ACS Chemical Biology, DOI: 10.1021/cb2003626

Antonio J. Martin-Galiano, María A. Oliva, Laura Sanz, Anamitra Bhattacharyya, Marina Serna, Hugo Yebenes, Jose M. Valpuesta and Jose M. Andreu [2011]. Bacterial Tubulin Distinct Loop Sequences and Primitive Assembly Properties Support its Origin from a Eukaryotic Tubulin Ancestor. J Biol Chem (doi: 10.1074/jbc.M111.230094)

Schaffner-Barbero C, Gil-Redondo R, Ruiz-Avila L, Huecas S, Läppchen T, den Blaauwen T, Diaz JF, Morreale A, Andreu JM [2010]. Insights into nucleotide recognition by cell division protein FtsZ from a mant-GTP competition assay and molecular dynamics. Biochemistry 49:10458-10472