Description In recent years total hip replacement with loss of function by metallic biomaterials has become an important concern in human health. The most widespread clinical intervention for hip substitution is given by the polyethylene/metal joint replacement. However, excessive wear of polyethylene causes the production of particles that is believed to be the major cause of the progressive bone loss (osteolysis) and subsequent loosening of prosthesis. This problem has strongly driven the use of the Metal on Metal (MoM) combinations as a replacement in joint prostheses, specifically, made of CoCr alloys, due to their substantially low corrosion and wear rates. But unfortunately, there are still wear particles with micro and nanometric sizes and ions that are released in the body with these implants. The known adverse reaction produced by MoM bearings in the human body seems to be due to the simultaneous presence of metallic nanoparticles, corrosion products and metallic ions. In our aim to understand the effect of the wear debris and ions from the tribocorrosion process of the MoM implants, cellular and biochemical studies are under study on cells that better represent the osteoarticular prostheses microenvironment. Members Head: Rosa María Lozano Puerto Group Cell-Biomaterial Recognition
