DESPOL is based on the use of biotechnological tools for gene desilencing of bioactive polyketide and non-ribosomal peptides in marine bacteria. The project aims to develop different biotechnological tools for "unmute" (enable) bacterial genes involved in the production of bioactive compounds that are not expressed in conventional culture conditions. Considering the premises: (i) there are lots of bacterial genes that are not expressed regularly and do not know which products could produce (silenced); (ii) many of these natural molecules synthesized genes most successful in medicine as therapeutics, such as polyketides and non-ribosomal peptides (antibiotics, antitumor, immunomodulators, etc.); (iii) molecular tools now exist to locate and act on silenced genes so that they can express themselves and be functional; (iv) it provides thousands of marine bacteria broad taxonomic diversity to be screened for the presence of these genes and their possible products.
This project is funded by the Retos-Colaboración program of MINECO (FEDER). The project is leaded by the company PharmaMar (Zeltia), with the collaboration of the University of Oviedo (Dr. José Antonio Salas) and the Center for Biological Research (Dr. José Luis García).

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