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Cell migration requires proteins with mechanical and signaling functions. Right: Schematic illustration of migrating cells with new adhesive traction points forming in the cell front and dissociating in the cell rear. Left: Atomic model of how mechanical and signaling proteins assemble during cell migration
Provided an atomic model for Focal Adhesion Kinase (FAK) force activation characterizing all interactions of the force transmitting tether to FAK
27 Apr 2025
Research
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CIB Margarita Salas receives the CSIC Center Lifetime Achievement Award in Transfer at the II Edition of the Transfer and Entrepreneurship Awards
16 Apr 2025
Research
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Microbial Biotechnology at the Service of Bioplastics: Sustainable Production of a New Strategic Monomer for the Synthesis of Bio-based Plastics
27 Feb 2025
Research
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CIB Margarita Salas receives the Sagrario Martínez Carrera Seal of Excellence awarded by CSIC
20 Feb 2025
Research
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Daniel Lietha was awarded one of the research grants of the Spanish Association Against Cancer in Madrid
17 Feb 2025
Research
Defects in mitochondrial respiratory complexes in brain tissues from ALS model transgenic mice. Cytochrome c oxidase (COX) and succinate dehydrogenase (SDH) activities are shown by double staining in sections of the cerebellum from mutant (SOD1G93A) and control (NTg) mice. In control sections, the purple stain representing SDH activity is masked by the brown stain representing COX activity, whereas the purple stain is prominently visible in mutant tissues. This suggests that COX activity is reduced in mutan
The mechanism by which the alteration of the function of the endoplasmic reticulum membrane associated with mitochondria modifies mitochondrial metabolism in ALS is revealed
23 Jan 2025
Research
ALL cells treated with a pharmacological inhibitor against LSD1 show a highly elongated morphology corresponding to a more invasive phenotype.
A new mechanism involved in disseminating acute lymphoblastic leukemia has been revealed
15 Jan 2025