Skip to main content
Peronne, L; Denarier, E.; Rai, A.; Prudent, R.; Vernet, A.; Suzanne, P.; Ramirez-Rios, S.; Michallet, S.; Guidetti, M.; Vollaire, J.; Lucena-Agell, D.; Ribba, A.S.; Josserand, V.; Coll, J.L.; Dallemagne, P.; Díaz, J.F.; Oliva, M.A.; Sadoul, K.; Akhmanova, A.; Andrieux, A.; Lafanechère, L.
[2020]. Two Antagonistic Microtubule Targeting Drugs Act Synergistically to Kill Cancer Cells. Cancers 12, 2196
Oliva, M.A.; Prota, A.E.; Rodríguez-Salarichs, J.; Gu, W.; Bennani, Y.L.; Jiménez-Barbero, J.; Bargsten, K.; Canales, A.; Steinmetz, M.O.; Díaz, J.F.
[2020]. Structural basis of noscapine activation for tubulin binding J. Med. Chem 63, 15, 8495–8501
Keenan, B., Finol‑Urdaneta, R.K.; Hope, A.; Bremner, J.B.; Kavallaris, M., Lucena‑Agell, D.; Oliva, M.A.; Díaz, J.F.; Vine, K.L.
[2020]. N‑alkylisatin‑based microtubule destabilizers bind to the colchicine site on tubulin and retain efficacy in drug resistant acute lymphoblastic leukemia cell lines with less in vitro neurotoxicity Cancer Cell Int 20:170
Estévez-Gallego, J.; Josa-Prado, F.; Ku, S.; Buey, R.M.; Balaguer, F.A., Prota, A.E.; Lucena-Agell, D.; Kamma-Lorger,C.; Steinmetz, M.O.; Barasoain,I.; Chrétien, D.; Kamimura, S.; Díaz, J.F.; Oliva, M.A.
[2020]. Structural model for differential cap maturation at growing microtubule ends (2020) eLife 2020, 9, e50155
Torres, M.D.; Flórez-Fernández, N.; Simón-Vázquez, R.; Giménez-Abián, J.F.; Díaz, J.F.; González-Fernández, A.; Domínguez, H.
[2020]. Fucoidans: The importance of processing on their anti-tumoral properties. Algal Research 45, 101748
Bonandi, E.; Foschi, F.; Dapiaggi, F.; Sironi, M.; Pieraccini, S.; Christodoulou, M.S.; Balaguer, F.A.; Díaz, J.F.; Zidar, N.; Passarella, D.
[2019]. Synthesis of thicolchicine-based conjugates: investigation towards bivalent tubulin/microtubules binders ChemPlusChem 84, 98–102
La Sala, G., Olieric,N.; Sharma, A.; Viti, F.; Balaguer Perez, F.A.;Huang, L; Tonra, J.R.; Lloyd, G.K.; Decherchi, S.; Díaz, J.F.; Steinmetz, M.O.; Cavalli, A.
[2019]. Structure, Thermodynamics, and Kinetics of Plinabulin Binding to Two Tubulin Isotypes Chem 5,11, 2969-2986
Brindisi, M.; Ulivieri, C.; Alfano, G.; Gemma, S.; Balaguer, F.A.; Khan, T.; Grillo, A.; Chemi, G.; Menchon, G.; Prota, A.E.; Olieric, N.; Lucena-Agell, D.; Barasoain, I.; Diaz, J.F.; Nebbioso, A.; Conte, M.R.; Lopresti, L.; Magnano, S.; Amet, R.; Kinsella,P.; Zisterer, D.M.; Ibrahim, O.; O'Sullivan, J.; Morbidelli,L.; Spaccapelo, R.; Baldari, C.; Butini, S.; Novellino,E.; Campiani, G.; Altucci, L.; Steinmetz, M.O.; Brogi S.
[2019]. Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents European Journal of Medicinal Chemistry 162 290-320
Bueno, O.; Gargantilla, M.; Estévez-Gallego, J.; Martins, S.; Díaz, J.F.; Camarasa, M.J.; Liekens,S.; Pérez‐Pérez, M.J.; Priego, E.M
[2019]. Diphenyl ether derivatives occupy the expanded binding site of cyclohexanedione compounds at the colchicine site in tubulin by movement of the αT5 loop. European Journal of Medicinal Chemistry 171, 195-208
Cury, N. M.; Mühlethaler, T.; Brunelli, A.; Laranjeira, A.; Canevarolo, R.R; Zenatti, P.P.; Lucena-Agell, D. Barasoain, I.; Song, C.; Sun, D., Dovat,S; Yunes, R.A.; Prota, A.E. Steinmetz,, M.O.; Díaz, J.F.; Yunes, J.A.
[2019]. Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia. iScience 21, 95–109
Unterhauser, K.; Pöltl, L.; Schneditz, G.; Kienesberger, S.; Glabonjat, R.A.; Kitsera, M.; Pletz, J.; Josa-Prado, F.; Dornisch, E.; Lembacher-Fadum, C.; Roier, S.; Gorkiewicze, G.; Lucena, D.; Barasoain,I.; Kroutil, W.; Wiedner, M.; Loizou, J.I.; Breinbauere, R.; Díaz, J.F.; Schilda, S.; Högenauer, C.; Zechner, E.L
[2019]. Klebsiella oxytoca enterotoxins tilimycin and tilivallinehave distinct host DNA-damaging and microtubule stabilizing activities PNAS 116 (9) 3774-3783
Gaugaz, F.Z.; Chicca, A.; Redondo-Horcajo, M.; Barasoain, I.; Díaz, J.F.; Altmann, K.H.
[2019]. Synthesis, Microtubule-Binding Affinity, and Antiproliferative Activity of New Epothilone Analogs and of an EGFR-Targeted Epothilone-Peptide Conjugate. (2019). Int. J. Mol. Sci. 2019, 20, 1113
Kuzniewski, C.N.; Glauser, S.; Gaugaz, F.Z.; Schiess, R.; Rodríguez-Salarichs, J.; Vetterli, S.; Horlacher, O.P.; Gertsch, J.; Redondo-Horcajo, M.; Canales, A.; Jiménez-Barbero, J.; Díaz, J.F.; Altmann, K.H.
[2019]. Synthesis, Profiling and Bioactive Conformation of trans-Cyclopropyl Epothilones Helv. Chim. Acta 102, 5 e1900078
Balaguer, F.A.; Mühlethaler, T.; Estévez-Gallego, J.; Calvo, E.; Giménez-Abián, J.F.; Risinger, A.L.; Sorensen, E.J.; Vanderwal, C.D.; Altmann, K.-H.; Mooberry, S.L.; Steinmetz, M.O.; Oliva,M.A.; Prota, A.E.; Díaz, J.F.
[2019]. Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands (2019) Int. J. Mol. Sci. 2019, 20, 1392
Rai, A.; Liu, T.; Glauser, S.; Katrukha, E.A.; Estévez-Gallego, J.; Rodríguez-García, R.; Fang, W.S.; Díaz, J.F.; Steinmetz,M.O.; Altmann, K.H.; Kapitein, L.C.; Moore, C.A.; Akhmanova, A.
[2019]. Taxanes convert regions of perturbed microtubule growth into rescue sites (2019) Nature Materials https://doi.org/10.1038/s41563-019-0546-6
Clara‐Rahola, J.; Casado‐Rodríguez, M.A,; Arrabal‐Campos, F. M.; Algarra, M.; López‐Romero, J.M.; Laurenti, M.; Fernández, I. Diaz, J.F.; , Rubio‐Retama, J.; Contreras‐Cáceres, R
[2018]. Synthesis, Characterization and Application of pH responsive Au@p4VP microgels as platform for Selective SERS Analysis. (2018) J. Colloid Interface Sci. 514, 704–714