Group Leader/s
Head of lab
intro
Our research explores the interface between chemical biology, medicinal chemistry, and supramolecular chemistry. We use modern analytical techniques to study dynamic combinatorial libraries, which are dynamic networks of interchanging chemical species. The team has developed chemistries that work under physiological conditions to gain insights into biological processes. We apply these dynamic networks in two research lines exploring protein modulation and synthetic antibody generation as sensors.
Members
| Ruth Perez Fernandez |
| Marc Hennebelle |
| Rafael Hortigüela Mecerreyes |
| Antonio Aguanell Aramendia |
| Carmen Chacon Tome |
| Suraiya Zaman |
| Maria Makogianni |
| Jorge Ortega Alonso |
| Ana Maria Dominguez Mantero |
| Alvaro Sarabia Vallejo |
| Romain Nuccio |
Selected Publications
Canal-Martín, A., Pérez-Fernández, R. [2021]. Biomimetic selenocystine based dynamic combinatorial chemistry for thiol-disulfide exchange. Nature Communications. 12:-.
Canal-Martín, A., Pérez-Fernández, R. [2020]. Protein-Directed Dynamic Combinatorial Chemistry: An Efficient Strategy in Drug Design. ACS Omega. 5:26307-26315.
Canal-Martín A, Sastre J, Sánchez-Barrena MJ, Canales A, Baldominos S, Pascual N, Martínez-González L, Molero D, Fernández-Valle ME, Sáez E, Blanco-Gabella P, Gómez-Rubio E, Martín-Santamaría S, Sáiz A, Mansilla A, Cañada FJ, Jiménez-Barbero J, Martínez A, Pérez-Fernández R. [2019]. Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library. Nat. Commun. 2019, 10, (1):2798. DOI: 10.1038/s41467-019-10627-w
Funding
La Caixa Health 2024. Redox metabolism as an Achilles' heel in malaria drug discovery. HR24-00445. PL: Dr. Ruth Pérez Fernández. Duration: 2024-2026.
ERC Consolidator grant 2023. Legonucleotides for detection. Chem2Sense. PI: Dr. Ruth Pérez Fernández. Duration: 2024-2029.
Activation and deactivation of proteins through dynamic combinatorial chemistry. PID2022-142565OB-I00 + FPI. PI: Dr. Ruth Pérez Fernández. Duration: 2023-2025.
Eco-efficient carbon capture and mineralization by dynamic-enzyme boosted approach. TED2021-132094B-I00. PI: Dr. Ruth Pérez Fernández. Duration: 2022-2024.
Protein-guided screening: accelerating drug discovery. PID2019-108587RB-I00. PI: Dr. Ruth Pérez Fernández. Duration: 2019-2023.