Group Leader/s
Head of lab
Group PI/s
intro
Our group has as main research interest the study of the metabolic and regulatory networks that control the bacterial metabolism of toxic compounds and/or biowaste, many of which are major environmental pollutants. The cell signaling circuits and the cognate resistance mechanisms involved in the bacterial adaptation to the stress caused by the toxic compounds are also under study. To this end, we carry out classic approaches of physiology, biochemistry and molecular biology, in combination with modern omic techniques and in silico metabolic models, to achieve an integrative and systems biology view. The acquired knowledge is also used to design, through systems metabolic engineering, recombinant microorganisms as biofactories for the conversion of contaminants/waste into added value products. The development of sustainable technologies to fix CO2, and to remove and revalorize contaminants and biowaste is a priority within the framework of a circular bio-economy.
Members
| Eduardo Díaz Fernández |
| Manuel Carmona Pérez |
| Carlos del Cerro Sanchez |
| Unai Fernández Arevalo |
| Helena Gomez Alvarez |
| Gonzalo Durante Rodríguez |
| Ana Valencia Hernando |
| Sofia de Francisco de Polando |
| Carla Sevilla Navarro |
| Sergio Vivo Filardi |
| Yolanda Gonzalez Perez |
| Elena Alonso Fernandes |
| Julia Marti Pages |
Selected Publications
Durante-Rodríguez G, de Francisco-Polanco S, García JL, Díaz E [2024]. Characterization of a MHYT domain-coupled transcriptional regulator that responds to carbon monoxide. Nucleic Acids Res. 52(15):8849-8860
Fernández-Arévalo U, Fuchs J, Boll M, Díaz E [2024]. Transcriptional regulation of the anaerobic 3-hydroxybenzoate degradation pathway in Aromatoleum sp. CIB. Microbiol Res. 288:127882
Durante-Rodríguez G, de Francisco-Polanco S, Fernández-Arévalo U, Díaz E [2024]. Engineering bacterial biocatalysts for the degradation of phthalic acid esters. Microb Biotechnol. 17(10):e70024
Castro, L., Gómez-Álvarez, H., González, F., & Muñoz, J. A. [2023]. Biorecovery of rare earth elements from fluorescent lamp powder using the fungus Aspergillus niger in batch and semicontinuous systems. Minerals Engineering, 201, 108215.
Castro, L., Gómez-Álvarez, H., Carmona, M., González, F., & Muñoz, J. A. [2023]. Influence of biosurfactants in the recovery of REE from monazite using Burkholderia thailandensis. Hydrometallurgy, 222, 106178.
Gómez-Álvarez H., Iturbe P., Rivero-Buceta V., Mines P., Bugg, T.D.H., Nogales, J., Díaz, E. [2022]. Bioconversion of lignin-derived aromatics into the building block pyridine 2,4-dicarboxylic acid by engineering recombinant Pseudomonas putida strains. Bioresour. Technol. 346:126638.
Sanz D., Díaz E. [2022]. Genetic characterization of the cyclohexane carboxylate degradation pathway in the denitrifying bacterium Aromatoleum sp. CIB. Environ. Microbiol. 24:4987-5004.
Valderrama, J.A., Gómez-Álvarez H., Martín-Moldes, Z., Berbís M.A., Cañada, F.J., Durante-Rodríguez, G., Díaz, E. [2019]. A novel redox-sensing histidine kinase that controls carbon catabolite repression in Azoarcus sp. CIB. mBio10(2):e00059-19
Fernández-Llamosas H, Castro L, Blázquez ML, Díaz E, Carmona M [2017]. Speeding up bioproduction of selenium nanoparticles by using Vibrio natriegens as microbial factory. Sci Rep. 22:16046
Zamarro MT, Martín-Moldes Z, Díaz E. [2016]. The ICEXTD of Azoarcus sp. CIB, an integrative and conjugative element with aerobic and anaerobic catabolic properties. Environ Microbiol. 18:5018-5031
Martín-Moldes Z, Blázquez B, Baraquet C, Harwood CS, Zamarro MT, Díaz E. [2016]. Degradation of cyclic diguanosine monophosphate by a hybrid two-component protein protects Azoarcus sp. strain CIB from toluene toxicity. Proc Natl Acad Sci U S A. 113:13174-13179.
Martínez I, Mohamed ME, Rozas D, García JL, Díaz E [2016]. Engineering synthetic bacterial consortia for enhanced desulfurization and revalorization of oil sulfur compounds. Metab Eng. 35:46-54.
Díaz E, Jiménez JI, Nogales J [2013]. Aerobic degradation of aromatic compounds. Curr. Opin. Biotechnol. 24: 431-442
Carmona M, Zamarro MT, Blázquez B, Durante-Rodríguez G, Juárez JF, Valderrama JA, Barragán MJL, García JL, Díaz E [2009]. The anaerobic catabolism of aromatic compounds: a genetic and genomic view. Microbiol Mol Biol Rev 73: 71-133
Jiménez JI, Canales A, Jiménez-Barbero J, Ginalski K, Rychlewski L, García JL, Díaz E [2008]. Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440. Proc Nat Acad Sci USA 105:11329-11334
Funding
Funding Agencies
Finished projects
- EU, QLK3-2000-00170 (2000-2003)
- CICYT, BIO2000-1076 (2000-2003)
- CICYT, GEN2001-4698-C05-02 (2003-2005)
- CAM, 07M/0076/2002 (2003-2004)
- CICYT, BIO2003-01482 (2004-2006)
- CICYT, VEM2003-20075-C02-02 (2004-2006)
- CAM, AMB-259-0505 (2006-2010)
- CSIC 2004 2 0E 073
- CICYT, BIO2006-05957 (2006-2009)
- CICYT, EU-SYSMO, GEN2006-27750-C5-3-E(2007-2010)- CICYT
- Consolider CSD2007-00005 (2008-2013)
- CICYT BIO2009-10438 (2009-2013)
- Aramco Overseas Company BV Contract No. 6600029601 (2012-2014)
- CICYT BIO2012-39501 (2013-2016)
- FP7-KBBE 311815 (2012-2016)
- CSIC 2016 2 0E 093 (2016-2018)
- MINECO PCIN-2014-113 (2015-2018)
- Ramón-Areces Fundation (XVII CN) (2015-2018)
- CICYT BIO2016-79736-R (2017-2019)
Active projects
- MICINN PID2019-110612RB-I00 (2020-2023)
- CSIC 2019 20E005 (2019-2021)
- H2020-NMBP-BIO-2017 (2018-2021)
- PCI2019-111833-2 (EU CoBiotech) (2020-2023)