Descripción

ααBacterial tubulin BtubA/B, the closest structural homolog of eukaryotic tubulin, has more primitive assembly properties and divergent surface loop sequences with intertwining features from α- and β-tubulin, suggesting evolution from a tubulin ancestor. BtubA/B folds without chaperones and assembles into microtubule-related polymers with potential biotechnological uses (Martin-Galiano 2011). TubZs are divergent tubulin-FtsZ homologs that assemble into double helical filaments constituting the motile fibres of type-III plasmid segregation systems. We have described the structure and assembly of TubZ encoded by the toxin carrying Clostridrium botulinum bateriophage cs-t, identified the TubR adaptor protein for segregation of the prophage and a TubY regulatory protein (Oliva 2012).

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