Responsable/s del laboratorio
Head of lab
Miembros
| Miguel Angel Vega Palacios |
| Angel Luis Corbí López |
| María Isabel Colmenares Brunet |
| Dora Beatriz Krimer Smunis |
| Concepción Nieto Mazarron |
| Ángeles Dominguez Soto |
| Cristina Herrero Pérez |
| Rodolfo Israel Ríos Hernández |
| Alejandro del Castillo Buey |
| Andres Cruz Martin |
| Michelle Milagros Davila Moreno |
| Alana Ventura Perez |
Publicaciones seleccionadas
Vega MA, Simón Fuentes M,Gonzalez de la Aleja A, Nieto C, Colmenares M, Herrero C, Domínguez-Soto A, Corbí AL. [2020]. MAFB and MAF transcription factors as macrophage checkpoints for COVID-19 severity. Front Immunol, in press, 2020
Cuevas VD, Anta L, Samaniego R, Orta-Zavalza E, Vladimir de la Rosa J, Baujat G, Domínguez-Soto Á, Sánchez-Mateos P, Escribese MM, Castrillo A, Cormier-Daire V, Vega MA, Corbí ÁL.
[2017]. MAFB Determines Human Macrophage Anti-Inflammatory Polarization: Relevance for the Pathogenic Mechanisms Operating in Multicentric Carpotarsal Osteolysis. J Immunol. 2017 Mar 1;198(5):2070-2081
Soler Palacios B, Nieto C, Fajardo P, González de la Aleja A, Andrés N, Dominguez-Soto A, Lucas P, Cuenda A, Rodríguez-Frade JM, Martínez-A C, Villares R, Corbí AL*, Mellado M*. [2020]. Growth hormone reprograms macrophages towards an anti-inflammatory and reparative profile in a MAFB-dependent manner. J Immunol. 2020 Aug 1;205(3):776-788.
Nieto C, Rayo I, de Las Casas-Engel M, Izquierdo E, Alonso B, Béchade C, Maroteaux L, Vega MA, Corbí ÁL. [2020]. Serotonin (5-HT) Shapes the Macrophage Gene Profile through the 5-HT 2B-Dependent Activation of the Aryl Hydrocarbon Receptor. J Immunol. 2020 May 15;204(10):2808-2817
Domínguez-Soto Á, Usategui A, Casas-Engel ML, Simón-Fuentes M, Nieto C, Cuevas VD, Vega MA, Luis Pablos J, Corbí AL. [2017]. Serotonin drives the acquisition of a profibrotic and anti-inflammatory gene profile through the 5-HT7R-PKA signaling axis. Sci Rep. 2017 Nov 7;7(1):14761.
Domínguez-Soto Á, Simón-Fuentes M, de Las Casas-Engel M, Cuevas VD, López-Bravo M, Domínguez-Andrés J, Saz-Leal P, Sancho D, Ardavín C, Ochoa-Grullón J, Sánchez-Ramón S, Vega MA, Corbí AL. [2018]. IVIg Promote Cross-Tolerance against Inflammatory Stimuli In Vitro and In Vivo. J Immunol. 2018 Jul 1;201(1):41-52
Riera-Borrull M, Cuevas VD, Alonso B, Vega MA, Joven J, Izquierdo E, Corbí AL. [2017]. Palmitate Conditions Macrophages for Enhanced Responses toward Inflammatory Stimuli via JNK Activation. J Immunol. 2017 Dec 1;199(11):3858-3869
Palacios, B.S., Estrada-Capetillo, L., Izquierdo, E., Criado, G., Nieto, C., Municio, C., González-Alvaro, I., Sánchez-Mateos, P., Pablos, J.L., Corbí, A.L., Puig-Kröger, A. [2015]. Macrophages from the synovium of active rheumatoid arthritis exhibit an activin a-dependent pro-inflammatory profile. Journal of Pathology. 235:515-526.
Aguilera-Montilla N, Chamorro S, Nieto C, Sánchez-Cabo F, Dopazo A, Fernández-Salguero PM, Rodríguez-Fernández JL, Pello OM, Andrés V, Cuenda A, Alonso B, Domínguez-Soto A, Sánchez-Ramón S, Corbí AL [2013]. Aryl hydrocarbon receptor contributes to the MEK/ERK-dependent maintenance of the immature state of human dendritic cells. BLOOD. 121: e108-e117
Elena Sierra-Filardi, Amaya Puig-Kröger, Francisco J. Blanco, Concha Nieto, Rafael Bragado, M. Isabel Palomero, Carmelo Bernabéu, Miguel A. Vega, and Angel L. Corbi [2011]. Activin A skews macrophage polarization by promoting a pro-inflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers. Blood
Fondos
1.- Dendritic cell differentiation: Role of cell adhesion in dendritic cellspecific transcription and analysis of expression and functional activities of DC-SIGN (CICYT, SAF2002-04615-C02-01, 2003-2006).
2.- Structural and Functional variability of DC-SIGN: Correlation with susceptibility to HIV and M. tuberculosis infection (FIPSE 36422/03). (FIPSE, 2004-2007).
3.- Effects of probiotics and biogenic amines on the phenotypic and functional properties of human dendritic cells and macrophages (CICYT, AGL2004-02148, 2004-2007; BIAMFOOD UE project, 7th Framework prog. 2007-2010).
4.- Gene expression profiling during differentiation and maturation of human dendritic cells (CICYT, GEN2003-20649-CO6-01, 2004-2007).
5.- DC-SIGN: A pathogen receptor involved in immunesurveillance (CAM, GR/SAL/0638/2004, 2005).
6.- Diferenciación y maduración de células dendríticas: Implicación de los factores de transcripción RUNX3 y PU.1, y actividades funcionales de DC-SIGN que determinan la susceptibilidad a la infección por HIV y otros patógenos (SAF2005-00021)
7.- Base molecular de la actividad pro-oncogénica y supresora de tumores del regulador transcripcional RUNX3 (Mutua Madrileña Automovilista)
8.- Activación de macrófagos: Identificación de moléculas implicadas en la adquisición de funciones efectoras proinflamatorias y anti-inflamatorias (BFU2008-01493).
9.- Molecular and cellular mechanisms in chronic inflammatory and autoinmmune diseases (MEICA project, 2009-2011).
10.- Análisis de los factores del sistema inmunitario innato implicados en la respuesta a la infección por el virus Influenza A (N1H1) V2009 (FIS, GR09/0013).
11.- Expression and function of polysialic acid on dendritic cells (FIS, PI07/0887, 2008-2010)
12.- Characterization of neuropilin-2 and the polysialyltransferase ST8SiaIV as potential therapeutic targets for control if immunity and cancer (FIS, PI10/00304, 2011-2013)