Group Leader/s
intro
The dynamism and plasticity of energy metabolism is key to cellular homeostasis. Changes in metabolic processes are essential for a correct cellular function but also the basis of several pathologies. Its high relevance as a pharmacological target has emerged as a biomedical discipline in the intervention not only in chronic metabolic diseases but also in the potential correction of metabolic anomalies that are in the etiology of oncological and infectious diseases. The group focuses its research on the characterization of alterations in cellular energy metabolism due to infections, particularly by Leishmania parasites, and pathologies such as cancer. The signalling pathways involved are analyzed to identify new drug targets, working on the design and characterization of new molecules, as well as on the repositioning of existing drugs. The group also investigates the use of the energy metabolism of Leishmania as a pharmacological target, a pathogen in which the group has a long research trajectory.
Members
| Eduardo Rial Zueco |
| Luis Ignacio Rivas López |
| José María Sánchez-Puelles González-Carvajal |
| Paula Martinez de Iturrate Sanz |
| Patricia de los Santos León |
| Jorge Fernandez Lajo |
| Juan Manuel Monteiro Ruiz |
| Marina Moreno Mayorga |
| Alba García Gomez |
| Angela Gutierrez Gutierrez |
| Imen Rabhi |
Selected Publications
Abengózar, M.A., Fernández-Reyes, M., Salazar, V.A., Torrent, M., de la Torre, B.G., Andreu, D., Boix, E., Rivas, L. [2022]. Essential role of enzymatic activity in the Leishmanicidal mechanism of the eosinophil cationic protein (RNase 3). ACS Infectious Diseases. 8:1207-1217.
Lima, M.L., Abengózar, M.A., Torres-Santos, E.C., Borborema, S.E.T., Godzien, J., López-Gonzálvez, Á., Barbas, C., Rivas, L., Tempone, A.G. [2022]. Energy metabolism as a target for cyclobenzaprine: A drug candidate against visceral Leishmaniasis. Bioorganic Chemistry. 127:106009
Tourmente, M., Sansegundo, E., Rial, E., Roldán, E. [2022]. Capacitation promotes a shift in energy metabolism in murine sperm. Frontiers in Cell and Developmental Biology. 10:950979
Sebastián-Pérez, V., Martínez de Iturrate, P., Nácher-Vázquez, M., Nóvoa, L., Pérezm, C., Campillo, N.E., Gil, C., Rivas, L. [2022]. Naphthoquinone as a New Chemical Scaffold for Leishmanicidal Inhibitors of Leishmania GSK-3. Biomedicines. 10:1136.
Pérez-Liébana, I., Juaristi, I., González-Sánchez, P., González-Moreno, L., Rial, E., Podunavac, M., Zakarian, A., Molgó, J., Vallejo-Illarramendi, A., Mosqueira-Martín, L., Lopez de Munain, A., Pardo, B., Satrústegui, J., Del Arco, A. [2022]. A Ca2+-dependent mechanism boosting glycolysis and OXPHOS by activating aralar-malate-aspartate shuttle, upon neuronal stimulation. Journal of Neuroscience. 42:3879-3895.
Cecchino, G.N., García-Velasco, J.A., Rial, E. [2021]. Reproductive senescence impairs the energy metabolism of human luteinized granulosa cells. Reproductive BioMedicine Online. 43:779-787.
Hendrickx, S., Van Bockstal, L., Bulté, D., Mondelaers, A., Aslan, H., Rivas, L., Maes, L., Caljon, G. [2020]. Phenotypic adaptations of Leishmania donovani to recurrent miltefosine exposure and impact on sand fly infection. Parasites and Vectors. 13:Article 96
Aguado, T., García, M., García, A., Ferrer-Mayorga, G., Martínez-Santamaría, L., Del Río, M., Botella, L.-M., Sánchez-Puelles, J.-M. [2020]. Raloxifene and n-Acetylcysteine Ameliorate TGF-Signalling in Fibroblasts from Patients with Recessive Dominant Epidermolysis Bullosa. Cells. 9:-.
Illa, O., Olivares, J.-A., Gaztelumendi, N., Martínez-Castro, L., Ospina, J., Abengozar, M.-Á., Sciortino, G., Maréchal, J.-D., Nogués, C., Royo, M., Rivas, L., Ortuño, R.M. [2020]. Chiral cyclobutane-containing cell-penetrating peptides as selective vectors for anti-leishmania drug delivery systems. International Journal of Molecular Sciences. 21:1-24.
Martínez de Iturrate, P., Sebastián-Pérez, V., Nácher-Vázquez, M., Tremper, C.S., Smirlis, D., Martín, J., Martínez, A., Campillo, N.E., Rivas, L., Gil, C. [2020]. Towards discovery of new leishmanicidal scaffolds able to inhibit Leishmania GSK-3. Journal of Enzyme Inhibition and Medicinal Chemistry. 35:199-210.
González-Sanz, S., Barreñada, O., Rial, E., Brieño-Enriquez, M.A., del Mazo, J. [2020]. The antiandrogenic vinclozolin induces differentiation delay of germ cells and changes in energy metabolism in 3D cultures of fetal ovaries. Scientific Reports. 10: Article 18036
Aguado, T., Romero-Revilla, J.A., Granados, R., Campuzano, S., Torrente-Rodríguez, R.M., Cuesta, Á.M., Albiñana, V., Botella, L.M., Santamaría, S., Garcia-Sanz, J.A., Pingarrón, J.M., Sánchez-Sancho, F., Sánchez-Puelles, J.-M. [2019]. 11PS04 is a new chemical entity identified by microRNA-based biosensing with promising therapeutic potential against cancer stem cells. Scientific Reports. 9: Article 11916
Funding
“Energy metabolism in the leishmania-macrophage interface: rationale for therapy intervention” Spanish Ministry of Science and Innovation (PID2019-108166GB-I00) (cofunded FEDER)
“Warburg rewiring triggered by coronavirus infection in the host cell: strategy for drug intervention” CSIC PTI Global Health (CSIC-COV19-110) (cofunded FEDER)
“Cooperative Research Network on Tropical Diseases (RICET)” Carlos III Health Institute (RETICS 2016 - RD16/0027/0010) (cofunded FEDER)
“Redox Biology and Medicine Research Network” Spanish Ministry of Science and Innovation (Red2018‐102576‐T) (cofunded FEDER)
“Bioenergetics characterization of human granulosa cells” Instituto Valenciano de Infertilidad (Madrid, Spain)
“Optimization of the therapeutic potential of leishmania protein kinases (PKs). Discovery of specific inhibitory drugs of the parasite PKs”. Spanish Ministry of Science and Innovation (SAF2015-65740-R) (cofunded FEDER)
“New electroanalytical multiplexing platforms for the detection and prognosis of neoplastic diseases by means of liquid biopsies” Spanish Ministry of Science and Innovation (CTQ2015-64402-C2-2-R) (cofunded FEDER)
More info
Recent Ph.D. Thesis
Daniela Saraiva Correa. Study of the bioenergetic alterations induced by synthetic compounds in Leishmania spp,Sao Paolo State University August, 2014. Co-supervised with Prof. André Gustavo Tempone.
María Fernández-Reyes Silvestre. Molecular basis for the activity and resistance of membrane-active peptides in prokaryotes. Their comparison with Leishmania as eukaryotic model Complutense University of Madrid June 2010.
Juan Román Luque-Ortega. The energetic metabolisms in Leishmania as target for new leishmanicidal molecules . Complutense University of Madrid . June 2008
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