Group Leader/s
intro
Energy metabolism is essential for the maintenance of cellular functions, thus, a drug target to treat a variety of pathologies. We investigate new mitochondrial inhibitors, membrane active peptides and disruptors of the signal transduction pathways involved in the regulation of the energy metabolism to fight, for example, against infection by the human protozoan parasite Leishmania or to sensitize cancer cells to chemotherapeutic agents
Members
| Eduardo Rial Zueco |
| Luis Ignacio Rivas López |
| José María Sánchez-Puelles González-Carvajal |
| Paula Martinez de Iturrate Sanz |
Selected Publications
Lima, M.L., Abengózar, M.A., Nácher-Vázquez, M., Martínez-Alcázar, M.P., Barbas, C., Tempone, A.G., López-Gonzálvez. A., Rivas, L. [2018]. Drug repurposing for Leishmania. Molecular basis of the leishmanicidal activity of the antidepressant sertraline. Antimicrobial Agents and Chemotheraphy. DOI: 10.1128/AAC.01928-18
Rivas, L., Nácher-Vázquez, M., Andreu, D. [2018]. Chapter 13: The Physical Matrix of the Plasma Membrane as a Target: The Charm of Drugs with Low Specificity. RSC Drug Discovery Series. 2018-January:248-281.
Martín-Sánchez, F., Martínez-García, J.J., Muñoz-García, M., Martínez-Villanueva, M., Noguera-Velasco, J.A., Andreu, D., Rivas, L., Pelegrín, P. [2017]. Lytic cell death induced by melittin bypasses pyroptosis but induces NLRP3 inflammasome activation and IL-1β release. Cell death & disease. 8:e2984-.
Abengózar, M.A., Cebrián, R., Saugar, J.M., Gárate, T., Valdivia, E., Martínez-Bueno, M., Maqueda, M., Rivas, L. [2017]. Enterocin AS-48 as evidence for the use of bacteriocins as new leishmanicidal agents. Antimicrobial Agents and Chemotherapy. 61:-.
Contreras, L., Rial, E., Cerdan, S., Satrustegui, J. [2017]. Uncoupling Protein 2 (UCP2) Function in the Brain as Revealed by the Cerebral Metabolism of (1–13C)-Glucose. Neurochemical Research. 42:108-114.
Rodríguez-Sánchez, L., Rial, E. [2017]. The distinct bioenergetic properties of the human UCP1. Biochimie. 134:51-55.
Nicholls, D.G., Rial, E. [2016]. A novel regulatory mechanism for the brown-fat uncoupling protein?. Nature Structural and Molecular Biology. 23:364-365.
Fernandez-Prada, C., Vincent, I.M., Brotherton, M.-C., Roberts, M., Roy, G., Rivas, L., Leprohon, P., Smith, T.K., Ouellette, M. [2016]. Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms. PLoS Neglected Tropical Diseases. 10:-.
Doménech, E., Maestre, C., Esteban-Martínez, L., Partida, D., Pascual, R., Fernández-Miranda, G., Seco, E., Campos-Olivas, R., Pérez, M., Megias, D., Allen, K., López, M., Saha, A.K., Velasco, G., Rial, E., Méndez, R., Boya, P., Salazar-Roa, M., Malumbres, M. [2015]. AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest. Nature Cell Biology. 17:1304-1316.
Moreira, D., Rodrigues, V., Abengozar, M., Rivas, L., Rial, E., Laforge, M., Li, X., Foretz, M., Viollet, B., Estaquier, J., Cordeiro da Silva, A., Silvestre, R. [2015]. Leishmania infantum Modulates Host Macrophage Mitochondrial Metabolism by Hijacking the SIRT1-AMPK Axis. PLoS Pathogens. 11:1-24.
Funding
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ISCIII PI12-02706(2013-2015)
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ISCIII-FEDER, RD12/0018/0007(2013-2015)
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FIS RICET RD06-0021-06 (2007-2014)
More info
More recent Ph.D. Thesis
Juan Román Luque-Ortega. The energetic metabolisms in Leishmania as target for new leishmanicidal molecules . Complutense University of Madrid . June 2008
Maria Fernández-Reyes Silvestre. Molecular basis for the activity and resistance of membrane-active peptides in prokaryotes. Their comparison with Leishmania as eukaryotic model Complutense University of Madrid June 2010. Daniela Saraiva Correa. Study of the bioenergetic alterations induced by synthetic compounds in Leishmania spp ,Sao Paolo State University August, 2014 . Co-supervised with Prof. André Gustavo Tempone.
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