Group Leader/s

 

intro

Energy metabolism is essential for the maintenance of cellular functions, thus, a drug target to treat a variety of pathologies. We investigate new mitochondrial inhibitors, membrane active peptides and disruptors of the signal transduction pathways involved in the regulation of the energy metabolism to  fight, for example, against infection by the human protozoan parasite Leishmania or to sensitize cancer cells to chemotherapeutic agents
 

Lima, M.L., Abengózar, M.A., Nácher-Vázquez, M., Martínez-Alcázar, M.P., Barbas, C., Tempone, A.G., López-Gonzálvez. A., Rivas, L.  [2018]. Drug repurposing for Leishmania. Molecular basis of the leishmanicidal activity of the antidepressant sertraline. Antimicrobial Agents and Chemotheraphy. DOI: 10.1128/AAC.01928-18

 

Funding

  1. ISCIII PI12-02706(2013-2015)
  2. ISCIII-FEDER, RD12/0018/0007(2013-2015)
  3. FIS RICET RD06-0021-06 (2007-2014)

 

 

More info

More recent Ph.D. Thesis

Juan Román Luque-Ortega. The energetic metabolisms in Leishmania as target for new leishmanicidal molecules . Complutense University of Madrid . June 2008

Maria Fernández-Reyes Silvestre. Molecular basis for the activity and resistance of membrane-active peptides in prokaryotes. Their comparison with Leishmania as eukaryotic model Complutense University of Madrid June 2010. Daniela Saraiva Correa. Study of the bioenergetic alterations induced by synthetic compounds in Leishmania spp ,Sao Paolo State University August, 2014 . Co-supervised with Prof. André Gustavo Tempone.

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