Our lab focuses in the use of chemical tools including nanoparticles to understand biological processes in pathological conditions. Among other materials, we use Quantum Dots (QDs) as luminescent particles to visualize molecular targets and monitor enzymatic activity. QDs offer a great potential to study biological systems due to their optimal photoluminescent properties and their versatility of conjugation to different biomolecules. Parallely, we work with peptides for different applications including cell penetrating systems and conjugation to nanoparticles.
Palomo V, Cistrone PA, Zhan N, Palui G, Mattoussi H, Dawson PE. . Efficient Assembly of Quantum Dots with Homogenous Glycans Derived from Natural N-Linked Glycoproteins. Bioconjug Chem. 29, 3144-3153.
Palomo V, Perez DI, Roca C, Anderson C, Rodríguez-Muela N, Perez C, Morales-Garcia JA, Reyes JA, Campillo NE, Perez-Castillo AM, Rubin LL, Timchenko L, Gil C, Martinez A. . Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases. J Med Chem. 60, 4983-5001.
Palomo V, Martinez A. . Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015). xpert Opin Ther Pat. 27, 657-666.
Palomo V, Díaz SA, Stewart MH, Susumu K, Medintz IL, Dawson PE. . 3,4-Dihydroxyphenylalanine Peptides as Nonperturbative Quantum Dot Sensors of Aminopeptidase. ACS Nano. 10, 6090-9.
Junior Leader la Caixa. Multiplexed Quantum Dot Immunoassay for the Improved Selection of Therapeutic Candidates for Motoneuron Diseases