Our lab focuses in the use of chemical tools including nanoparticles to understand biological processes in pathological conditions. Among other materials, we use Quantum Dots (QDs) as luminescent particles to visualize molecular targets and monitor enzymatic activity. QDs offer a great potential to study biological systems due to their optimal photoluminescent properties and their versatility of conjugation to different biomolecules. Parallely, we work with peptides for different applications including cell penetrating systems and conjugation to nanoparticles.
Palomo V, Cistrone PA, Zhan N, Palui G, Mattoussi H, Dawson PE. . Efficient Assembly of Quantum Dots with Homogenous Glycans Derived from Natural N-Linked Glycoproteins. Bioconjug Chem. 29, 3144-3153.
Palomo V, Perez DI, Roca C, Anderson C, Rodríguez-Muela N, Perez C, Morales-Garcia JA, Reyes JA, Campillo NE, Perez-Castillo AM, Rubin LL, Timchenko L, Gil C, Martinez A. . Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases. J Med Chem. 60, 4983-5001.
Palomo V, Martinez A. . Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015). xpert Opin Ther Pat. 27, 657-666.
Palomo V, Díaz SA, Stewart MH, Susumu K, Medintz IL, Dawson PE. . 3,4-Dihydroxyphenylalanine Peptides as Nonperturbative Quantum Dot Sensors of Aminopeptidase. ACS Nano. 10, 6090-9.
Junior Leader la Caixa.
Project title: Multiplexed Quantum Dot Immunoassay for the Improved Selection of Therapeutic Candidates for Motoneuron Diseases.
February 2019: Interview with Nobbot, read it here (only available in Spanish)
February 2019: Jan Pfeiffer, Isabel Delgado and Isabel Barrena join the group as undergrad and master's students. Welcome all!
December 2018: Rebeca París joins the group as a student. Welcome Rebeca!