Group Leader/s

 

intro

T lymphocyte activation and differentiation involves antigen recognition plus interaction between costimulatory molecules and their ligands in myeloid cells. These interactions deliver signals that are essential to mount immune responses against pathogens and cancer, or to develop autoimmune diseases. Our interest is focused on the role of CD28, the CD28 homolog molecule ICOS (CD278), the ICOS ligand (ICOS-L, B7h, CD275), and PI3K signals in T lymphocyte, NK cell and antigen presenting cells in vitro or in vivo using pharmacologic and genetic approaches. We are also interested in the use and impact of nanomaterials to modulate innate and adaptive immunity.

 

 

Members

Staff Scientists
José María Rojo Hernández
Team Image
 

Estrada-Capetillo L, Aragoneses-Fenoll L, Domínguez-Soto A, Fuentelsaz-Romero S, Nieto C, Simón-Fuentes M, Alonso B, Portolés P, Corbí AL, Rojo JM, Puig-Kröger A  [2020]. CD28 is expressed by macrophages with anti-inflammatory potential and limits their T cell activating capacity. European Journal of Immunology. doi: 10.1002/eji.202048806

 

Funding

Grant SAF2017-89672-R: “Lipid rafts y entorno tumoral inflamatorio en la terapia del cáncer: Análogos alquilfosfolípidos como agentes dirigidos frente a lipid rafts e inflamación con múltiples indicaciones terapéuticas”. Agencia Estatal de Investigación.
PI: Faustino Mollinedo (01/2018-12/2020)

Grant PI13/01809: “ICOS, ICOS ligand and Class IA PI3-kinases as targets in immunotherapy". Acción Estratégica en Salud, IS Carlos III (01/2014-09/2017)

Grant PI10/00650: “ICOS signaling in costimulation and adhesion, conditioned deficiency in T lymphocyte lineages, and impact in autoimmune inflammatory diseases” AES, IS Carlos III (01/2011-12/2013)

Grant PI070620: “Mechanisms of activation by ICOS (CD278): Pro- and anti-inflammatory effects in Experimental Allergic Encephalitis” Fondo de Investigación Sanitaria, IS Carlos III (11/2007-11/2010)

Grant SAF2004-06852, "Inducible Costimulator (ICOS): Integration of costimulatory pathways in T lymphocytes and specific signaling" MEC, Programa Nacional de Salud y Farmacia (12/2004-12/2007).

Grant BMC2001-2177, “Variability mechanisms of “invariant” CD3ε chains of T lymphocyte TCR/CD3 complex: Changes in complex structure and activation signals" MCyT, Programa Nacional de Promoción General del Conocimiento (12/ 2001-12/2004)

 

More info

PhD Thesis

Acosta Ampudia YY (2013) "Association of Class IA PI3-kinase subunits to ICOS (CD278) and relevance to costimulation" PhD Thesis, Facultad de Ciencias Biológicas, Universidad Complutense de Madrid. Director: Rojo, JM. Summa “cum laude”.

Bello R (2007) "Immunological and functional analysis of CD3ε chains of the TCR/CD3 complex". PhD Thesis, Facultad de Ciencias Biológicas, Universidad Complutense de Madrid. Director: Rojo, JM. Summa “cum laude”.

Sánchez, A (2006) "Analysis of costimulatory effect of CD46 (MCP) in CD4+ T lymphocytes. Interaction with pathogens and search of potential ligands". PhD Thesis, Facultad de Ciencias Biológicas, Universidad Complutense de Madrid. Director: Rojo, JM. Summa “cum laude”.