Cellular and molecular basis of alzheimer´s disease and other dementias

Our group is engaged in a research project aimed at evaluating the potential contribution of cell cycle control failure to neurodegeneration in Alzheimer’s disease and other dementias, as well as in other neurodegenerative disorders such as Amiotrophic Lateral Sclerosis or Parkinson disease. The innovative aspect of their work is to consider non-neuronal cells from patients, as suitable model to study cell proliferation and apoptosis events associated with neurodegenerative pathogenesis. In addition neuronal cultures and murine models are used as experimental models.

Ad Honorem
María Angeles Martín Requero

Visitors
Victor Arroyo López

Cuevas EP, Rodríguez-Fernández A, Palomo V, Martínez A, Martín-Requero Á [2022]. TDP-43 Pathology and Prionic Behavior in Human Cellular Models of Alzheimer’s Disease Patients. Biomedicines 10(2):385

Martín-Cámara O, Arribas M, Wells G, Morales-Tenorio M, Martín-Requero Á, Porras G, Martínez A, Giorgi G, López-Alvarado P, Lastres-Becker I, Menéndez JC [2022]. Multitarget Hybrid Fasudil Derivatives as a New Approach to the Potential Treatment of Amyotrophic Lateral Sclerosis.J Med Chem. 2022 Jan 5. doi: 10.1021/acs.jmedchem.1c01255. Online ahead of print.PMID: 34985276

Nozal V, Martínez-González L, Gomez-Almeria M, Gonzalo-Consuegra C, Santana P, Chaikuad A, Pérez-Cuevas E, Knapp S, Lietha D, Ramírez D, Petralla S, Monti B, Gil C, Martín-Requero A, Palomo V, de Lago E, Martinez A [2022]. TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy.J Med Chem. 2022 Jan 27;65(2):1585-1607

Martínez-González, L.; Gonzalo-Consuegra, C; Gómez-Almeria. M.; Porras, G.; de Lago, E.;Martín-Requero, A.: Martínez, A. Int. J. Mol. Sci 2021, Volume 22, Issue 16, 8975I [2021]. Tideglusib, a Non-ATP Competitive Inhibitor of GSK-3β as a Drug Candidate for the Treatment of Amyotrophic Lateral Sclerosis

Lastres-Becker, I.; Porras, G.; Arribas-Blázquez, M.; Maestro, I.; Borrego-Hernández, D.; Boya, P.; Cerdán, S.; García-Redondo, A.; Martínez, A.; Martin-Requero, Á [2021]. Molecular Alterations in Sporadic and SOD1-ALS Immortalized Lymphocytes: Towards a Personalized Therapy. Int. J. Mol. Sci. 2021, 22, 3007

Tosat-Bitrian C, Avis-Bodas A, Porras G, Borrego-Hernández D, García-Redondo A, Martin-Requero A, Palomo V. [2021]. CdSe Quantum Dots in Human Models Derived from ALS Patients: Characterization, Nuclear Penetration Studies and Multiplexing,Nanomaterials 2021, 11(3), 671

Rojas-Prats E, Martinez-Gonzalez L, Gonzalo-Consuegra C , Liachko NF, Perez C, Ramírez D, Kraemer BC, Martin-Requero A, Perez DI, Gil C, de Lago E, Martinez A [2020]. Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral sclerosis, Eur J Med Chem. 2020 Oct 28;112968

Alquezar C, Martin-Requero A [2020]. Wnt Signalling in Dementia, in "The Neuroscience of Dementia" Elsevier (Martin CR and Preedy VR Eds) pp. 177-193

Vaca G, Martinez-Gonzalez L, Fernandez A, Rojas-Prats E, Porras G, Cuevas EP, Gil C, Martinez A,Martin-Requero Á. [2020]. Therapeutic potential of novel Cell Division Cycle Kinase 7 inhibitors on TDP-43-related pathogenesis such as Frontotemporal Lobar Degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) J. Neurochem. doi: 10.1111/jnc.15118

Martín-Gnzález L, Rodríguez-Cueto C, Cabezudo D, Bartolomé F, Andrés-Benito P, Ferrer I, Gil C, Martín-Requero A, Fernández-Ruiz Jm Martínez A, de Lago E [2020]. Motor neuron preservation and decrease of in vivo TDP-43 phosphorylation by protein CK-1δ kinase inhibitor treatment. Sci Rep 10, 4449 (2020)

All Publications

SAF2007-6245: Molecular interactions between Ca2+/Calmodulin and the cell survival/death signaling pathways in non-neuronal cells from patients suffering from Azheimer’ disease and other dementias.

Fundación Eugenio Rodríguez Pascual (2009-2010): Control of cell proliferation and apoptosis in Alzheimer’s disease. Studies in non-neuronal cells from patients and in Tg APP/PS1 mice.

SAF210-15700: Role of Progranulin on the mechanisms of regulation of cell survival/death in the frontotemporal lobar degeneration.

SAF2011-28630: Molecular neurodegenerative mechanisms in the frontotemporal lobar degeneration (FTLD-TDP): Progranulin deficit, cell cycle dysfunction and TDP-43 accumulation (2012-2015)

CIBERER Proyecto Intramural PIBER 3 (Ref #11-734/11202 (2011)

Fundación Ramón Areces XVI Concurso nacional:

Mecanismos moleculares, modelos experimentales y aproximaciones terapéuticas en la Demencia Lobar Frontotemporal (DLFT-TDP)

(2012-2015)

CTQ2015-66313-R: Quimio-computación en el descubrimiento de rármacos multidiana para el tratamientode la enfermedad de Alzheimer

(2015-2017)

Currently no information is available

Group Leader/s

María Angeles Martín Requero

intro

Research lines

Cellular and molecular basis of of Alzheimer´s disease. Relevance of non.neuronal studies.

Progranulin haploinsufficciency and Frontotemporal lobar degeneration (FTLD-TDP)

Members

Selected Publications

Cuevas EP, Rodríguez-Fernández A, Palomo V, Martínez A, Martín-Requero Á [2022]. TDP-43 Pathology and Prionic Behavior in Human Cellular Models of Alzheimer’s Disease Patients. Biomedicines 10(2):385

Tosat-Bitrian C, Avis-Bodas A, Porras G, Borrego-Hernández D, García-Redondo A, Martin-Requero A, Palomo V. [2021]. CdSe Quantum Dots in Human Models Derived from ALS Patients: Characterization, Nuclear Penetration Studies and Multiplexing,Nanomaterials 2021, 11(3), 671

Alquezar C, Martin-Requero A [2020]. Wnt Signalling in Dementia, in "The Neuroscience of Dementia" Elsevier (Martin CR and Preedy VR Eds) pp. 177-193

Funding

More info