In nature, plants are living in constantly changing environments that are often unfavorable or stressful for growth and development. Adverse environmental conditions, including drought, extreme temperatures, and salinity, constitute major limiting factors for plant geographical distribution and productivity in agriculture, and threaten food security. These conditions are expected to increase along this century due to drastic changes in climate, much of which are driven by global warming. As a consequence, agriculture and the way our crops grown, as well as the way in which our ecosystems evolve will be greatly affected.
To survive the environmental stress conditions to which they are often exposed, plants modify their metabolism and growth by reprogramming gene expression. Although many stress-regulated genes have already been identified and characterized, the molecular mechanisms underlying those adaptive responses still are not well understood. Elucidating these mechanisms, in addition of being a fundamental biological question, is critical to improve stress tolerance in crops to achieve agricultural sustainability and food security for a growing world population.
Our research program is aimed to identify and characterize the molecular mechanisms of plant adaptation and tolerance to abiotic stresses. Using Arabidopsis as a model system and a multidisciplinary approach, including a combination of genetic, biochemical, cell biology, genomic and proteomic experimental strategies, we have identified molecular regulators involved at different levels (chromatin/epigenetic, transcriptional and posttranscriptional) in plant adaptation to adverse environments. Current efforts are mainly dedicated to understand the way of action of these elements and their roles in abiotic stress responses. The conservation of the molecular regulators identified in Arabidopsis in important crops such as tomato is also being a subject of study.
Esteve-Bruna, D., Carrasco-López, C., Blanco-Touriñán, N., Iserte, J., Calleja-Cabrera, J., Perea-Resa, C., Úrbez, C., Carrasco, P., Yanovsky, M.J., Blázquez, M.A., Salinas, J., Alabadí, D. . Prefoldins contribute to maintaining the levels of the spliceosome LSM2-8 complex through Hsp90 in Arabidopsis. Nucleic acids research. 48:6280-6293.
Perea-Resa, C., Catalá, R., Salinas, J. . Identification of Arabidopsis Mutants with Altered Freezing Tolerance. Methods in Molecular Biology. 2156:85-97.
Costa-Broseta, Á., Perea-Resa, C., Castillo, M.-C., Ruíz, M.F., Salinas, J., León, J. . Nitric oxide deficiency decreases C-repeat binding factor-dependent and -independent induction of cold acclimation. Journal of Experimental Botany. 70:3283-3296.
Huertas, R., Catalá, R., Jiménez-Gómez, J.M., Mar Castellano, M., Crevillén, P., Piñeiro, M., Jarillo, J.A., Salinas, J. . Arabidopsis SME1 Regulates Plant Development and Response to Abiotic Stress by Determining Spliceosome Activity Specificity. Plant Cell. 31:537-554.
Catalá, R., Carrasco-López, C., Perea-Resa, C., Hernández-Verdeja, T., Salinas, J. . Emerging roles of lsm complexes in posttranscriptional regulation of plant response to abiotic stress. Frontiers in Plant Science. 10:-.
Olate, E., Jiménez-Gómez, J.M., Holuigue, L., Salinas, J. . NPR1 mediates a novel regulatory pathway in cold acclimation by interacting with HSFA1 factors. Nature Plants. 4:811-823
Barrero-Gil J., Salinas J. . Gene Regulatory Networks Mediating Cold Acclimation: The CBF Pathway. In: Iwaya-Inoue M., Sakurai M., Uemura M. (eds) Survival Strategies in Extreme Cold and Desiccation. Advances in Experimental Medicine and Biology, vol 1081:3-22 Springer, Singapore
Catalá, R., Salinas, J. . Tailoring crop nutrition to fight weeds. Proc Natl Acad Sci USA 115 (29) 7456-7458. doi.org/10.1073/pnas.1809311115
Costa-Broseta, Á., Perea-Resa, C., Castillo, M.-C., Ruíz, M.F., Salinas, J., León, J. . Nitric Oxide Controls Constitutive Freezing Tolerance in Arabidopsis by Attenuating the Levels of Osmoprotectants, Stress-Related Hormones and Anthocyanins. Scientific Reports. 8 (1).
Egea, I., Pineda, B., Ortíz-Atienza, A., Plasencia, F.A., Drevensek, S., García-Sogo, B., Yuste-Lisbona, F.J., Barrero-Gil, J., Atarés, A., Flores, F.B., Barneche, F., Angosto, T., Capel, C., Salinas, J., Vriezen, W., Esch, E., Bowler, C., Bolarín, M.C., Moreno, V., Lozano, R. . The SLCBl10 calcineurin B-Like protein ensures plant growth under salt stress by regulating Na+ and Ca2+ homeostasis. Plant Physiology. 176:1676-1693.
- Project: BIO2016-79187-R - Title: Unveiling new regulatory mechanisms of pre-mRNA splicing involved in plant tolerance to freezing and related abiotic stresses - Funding Agency: AEI/FEDER - PI: J. Salinas
- Project: PID2019-106987RB-100 – Title: Uncovering the function of Arabidopsis PAT1 mRNA decapping activators as new regulators of plant tolerance to abiotic stress – Funding Agency: AEI - PI: J. Salinas