Group Leader/s



Our group has as main research interest the study of the metabolic and regulatory networks that control the bacterial metabolism of toxic compounds and/or biowaste, many of which are major environmental pollutants. The cell signaling circuits and the cognate resistance mechanisms  involved in the bacterial adaptation to the stress caused by the toxic compounds are also under study. To this end, we carry out classic approaches of physiology, biochemistry and molecular biology, in combination with modern omic techniques and in silico metabolic models, to achieve an integrative and systems biology view. The acquired knowledge is also used to design, through systems metabolic engineering, recombinant microorganisms as biofactories for the conversion of contaminants/waste into added value products. The development of sustainable technologies to fix CO2, and to remove and revalorize contaminants and biowaste is a priority within the framework of a circular bio-economy.


Durante-Rodríguez G, Gómez-Álvarez H, Blázquez B, Fernández-Llamosas H, Martín-Moldes Z, Sanz D, Nogales J, Carmona M, Díaz E  [2018]. Anaerobic pathways for the catabolism of aromatic compounds. In Book: Lignin valorization: emerging approaches. Edited by Gregg T. Beckham. pp. 333-390

Martínez I, El-Said Mohamed M, Santos VE, García JL, García-Ochoa F, Díaz E  [2017]. Metabolic and process engineering for biodesulfurization in Gram-negative bacteria. J Biotechnol 262:47-55



Funding Agencies

Finished projects

  • EU, QLK3-2000-00170 (2000-2003)
  • CICYT, BIO2000-1076 (2000-2003)
  • CICYT, GEN2001-4698-C05-02 (2003-2005)
  • CAM, 07M/0076/2002 (2003-2004)
  • CICYT, BIO2003-01482 (2004-2006)
  • CICYT, VEM2003-20075-C02-02 (2004-2006)
  • CAM, AMB-259-0505 (2006-2010)
  • CSIC 2004 2 0E 073
  • CICYT, BIO2006-05957 (2006-2009)
  • CICYT, EU-SYSMO, GEN2006-27750-C5-3-E(2007-2010)- CICYT
  • Consolider CSD2007-00005 (2008-2013)
  • CICYT BIO2009-10438 (2009-2013)
  • Aramco Overseas Company BV Contract No. 6600029601 (2012-2014)

Active projects

  • CICYT BIO2012-39501 (2013-2015)
  • FP7-KBBE 311815 (2012-2016)
  • MINECO PCIN-2014-113
  • CAM S2013/ABI-2783
  • Ramón-Areces Fundation (XVII CN)
  • CICYT BIO2016-79736-R (2017-2019)

More info

Currently no information is available