Functions of chemotactic receptors and the immunological synapse in dendritic cells

TITULO: Mecanismos moleculares usados por el receptor de quimioquinas CCR7 y la sinapsis inmunológica autoinmune para controlar las funciones de las células dendríticas.

FECHA INICIO y FINALIZACION: 2018-2020

Predoctoral Fellowship

Funciones de los receptores quimiotácticos y la sinapsis inmunológica

Se buscan candidato/a para SOLICITAR beca FPU (plazo termina el 20 de Diciembre). Ver tema de trabajo del grupo en nuestra página web:

Laboratory

Functions of chemotactic receptors and the immunological synapse in dendritic cells

CIB Contact

José Luis Rodríguez Fernández

Currently no information is available

Group Leader/s

José Luis Rodríguez Fernández

intro

Research lines

Molecular mechanisms that regulate the functions of chemokine receptors in dendritic cells

Regulatory functions of the immunological synapse of dendritic cells

Members

Selected Publications

Rodríguez-Fernández JL, Criado-García O. [2020]. The Chemokine Receptor CCR7 Uses Distinct Signaling Modules With Biased Functionality to Regulate Dendritic Cells. FRONT. IMMUNOL. 11:528

Gómez-Cabañas L, López-Cotarelo P, Criado-García O, Murphy MP, Boya P, Rodríguez-Fernández JL. [2019]. Immunological Synapse Formation Induces Mitochondrial Clustering and Mitophagy in Dendritic Cells. J IMMUNOL. 202: 1715-1723

Martínez-Muñoz L, Villares R, Rodríguez-Fernández JL, Rodríguez-Frade JM, Mellado M. [2018]. Remodeling our concept of chemokine receptor function: From monomers to oligomers. J LEUKOC BIOL 104:323-331

López-Cotarelo, P. Gómez-Moreira, C, Criado-García O., Sánchez, L and Rodríguez-Fernández, JL [2017]. Beyond Chemoattraction: Multifunctionality of Chemokine Receptors in Leukocytes. TRENDS IMMUNOL. 38, 927-941

Torres-Bacete J, Delgado-Martín C, Gómez-Moreira C, Simizu S, Rodríguez-Fernández JL. [2015]. The Mammalian Sterile 20-like 1 Kinase Controls Selective CCR7-Dependent Functions in Human Dendritic Cells. J. IMMUNOL. 195: 973-981

Cascio G, Martín-Cófreces NB, Rodríguez-Frade JM, López-Cotarelo P, Criado G, Pablos JL, Rodríguez-Fernández JL, Sánchez-Madrid F, Mellado M. [2015]. CXCL12 Regulates through JAK1 and JAK2 Formation of Productive Immunological Synapses. J IMMUNOL. 194:5509-19

Rodríguez-Fernández JL, García de Lacoba M [2015]. Plasma membrane-associated superstructure: Have we overlooked a new type of organelle in eukaryotic cells? J. THEOR. BIOL. 380:346-358

Funding

Fellowships and jobs

Funciones de los receptores quimiotácticos y la sinapsis inmunológica

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