Publications | Centro de Investigaciones Biológicas Margarita Salas - CIB Margarita Salas

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Li, B., Li, Y., Tomkiewicz-Raulet, C., Dao, P., Lietha, D., Yen-Pon, E., Du, Z., Coumoul, X., Garbay, C., Etheve-Quelquejeu, M., Chen, H. [2020]. Design, Synthesis, and Biological Evaluation of Covalent Inhibitors of Focal Adhesion Kinase (FAK) against Human Malignant Glioblastoma. J Med Chem. :-.

Acebron, I., Righetto, R. D., Schoenherr, C., de Buhr, S., Redondo, P., Culley, J., Rodriguez, C. F., Daday, C., Biyani, N., Llorca, O., Byron, A., Chami, M., Grater, F., Boskovic, J., Frame, M. C., Stahlberg, H., Lietha, D. [2020]. Structural basis of Focal Adhesion Kinase activation on lipid membranes. EMBO J. 39:e104743-.

Lietha, D., Izard, T. [2020]. Roles of Membrane Domains in Integrin-Mediated Cell Adhesion. Int J Mol Sci. 21:-.

Tapial Martinez, P., Lopez Navajas, P., Lietha, D. [2020]. FAK Structure and Regulation by Membrane Interactions and Force in Focal Adhesions. Biomolecules. 10:-.

Dawson, J. C., Serrels, B., Byron, A., Muir, M. T., Makda, A., Garcia-Munoz, A., von Kriegsheim, A., Lietha, D., Carragher, N. O., Frame, M. C. [2020]. A Synergistic Anticancer FAK and HDAC Inhibitor Combination Discovered by a Novel Chemical-Genetic High-Content Phenotypic Screen. Mol Cancer Ther. 19:637-649-.

Bauer, M. S., Baumann, F., Daday, C., Redondo, P., Durner, E., Jobst, M. A., Milles, L. F., Mercadante, D., Pippig, D. A., Gaub, H. E., Grater, F., Lietha, D. [2019]. Structural and mechanistic insights into mechanoactivation of focal adhesion kinase. Proc Natl Acad Sci U S A. 116:6766-6774-.

Toledo, R. A., Garralda, E., Mitsi, M., Pons, T., Monsech, J., Vega, E., Otero, A., Albarran, M. I., Banos, N., Duran, Y., Bonilla, V., Sarno, F., Camacho-Artacho, M., Sanchez-Perez, T., Perea, S., Alvarez, R., De Martino, A., Lietha, D., Blanco-Aparicio, C., Cubillo, A., Dominguez, O., Martinez-Torrecuadrada, J. L., Hidalgo, M. [2018]. Exome Sequencing of Plasma DNA Portrays the Mutation Landscape of Colorectal Cancer and Discovers Mutated VEGFR2 Receptors as Modulators of Antiangiogenic Therapies. Clin Cancer Res. 24:3550-3559-.

Le Coq, J., Camacho-Artacho, M., Velazquez, J. V., Santiveri, C. M., Gallego, L. H., Campos-Olivas, R., Dolker, N., Lietha, D. [2017]. Structural basis for interdomain communication in SHIP2 providing high phosphatase activity. Elife. 6:-.

Yen-Pon, E., Li, B., Acebron-Garcia-de-Eulate, M., Tomkiewicz-Raulet, C., Dawson, J., Lietha, D., Frame, M. C., Coumoul, X., Garbay, C., Etheve-Quelquejeu, M., Chen, H. [2018]. Structure-Based Design, Synthesis, and Characterization of the First Irreversible Inhibitor of Focal Adhesion Kinase. ACS Chem Biol. 13:2067-2073-.

Dao, P., Lietha, D., Etheve-Quelquejeu, M., Garbay, C., Chen, H. [2017]. Synthesis of novel 1,2,4-triazine scaffold as FAK inhibitors with antitumor activity. Bioorg Med Chem Lett. 27:1727-1730-.

Lietha, D. [2016]. Forcing FAK into Transcriptional Activity. Structure. 24:1223-1225-.

Le Coq, J., Heredia Gallego, L., Lietha, D. [2016]. Expression, Purification, Crystallisation and X-ray Crystallographic Analysis of a Truncated Form of Human Src Homology 2 Containing Inositol 5-Phosphatase 2. Protein J. 35:225-30-.

Zhou, J., Bronowska, A., Le Coq, J., Lietha, D., Grater, F. [2015]. Allosteric regulation of focal adhesion kinase by PIP(2) and ATP. Biophys J. 108:698-705-.

Dao, P., Smith, N., Tomkiewicz-Raulet, C., Yen-Pon, E., Camacho-Artacho, M., Lietha, D., Herbeuval, J. P., Coumoul, X., Garbay, C., Chen, H. [2015]. Design, synthesis, and evaluation of novel imidazo[1,2-a][1,3,5]triazines and their derivatives as focal adhesion kinase inhibitors with antitumor activity. J Med Chem. 58:237-51-.

Balzano, D., Fawal, M. A., Velazquez, J. V., Santiveri, C. M., Yang, J., Pastor, J., Campos-Olivas, R., Djouder, N., Lietha, D. [2015]. Alternative Activation Mechanisms of Protein Kinase B Trigger Distinct Downstream Signaling Responses. J Biol Chem. 290:24975-85-.

Goni, G. M., Epifano, C., Boskovic, J., Camacho-Artacho, M., Zhou, J., Bronowska, A., Martin, M. T., Eck, M. J., Kremer, L., Grater, F., Gervasio, F. L., Perez-Moreno, M., Lietha, D. [2014]. Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes. Proc Natl Acad Sci U S A. 111:E3177-86-.

Frame, M. C., Patel, H., Serrels, B., Lietha, D., Eck, M. J. [2010]. The FERM domain: organizing the structure and function of FAK. Nat Rev Mol Cell Biol. 11:802-14-.

Lietha, D., Cai, X., Ceccarelli, D. F., Li, Y., Schaller, M. D., Eck, M. J. [2007]. Structural basis for the autoinhibition of focal adhesion kinase. Cell. 129:1177-87-.