Description

The development of synthetic molecules that mimics the precision of nature in molecular recognition represents a huge challenge to chemists. Dynamic combinatorial chemistry (DCC) holds enormous potential for drug discovery. In Dynamic Combinatorial Chemistry (DCC), building blocks react with one another using reversible chemical reactions giving mixtures of oligomers (Dynamic combinatorial libraries, DCLs). The composition of the DCLs after reaching equilibrium is determined by the relative stabilities of the different library members. If a target molecule is added to the system and one or more molecules show affinity to the target species, these compounds will, according to Le Chatelier's principle, be amplified on the expense of the other non-bonding constituents. The identification of the best binders avoids the need for synthesis, purification and characterization of each library member, speeding the identification and optimization of novel ligands for biological targets.

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