The number of class D carbapenemases identified in hospitals worldwide continues to grow significantly. Most of them have been isolated from gram-negative pathogens. Our more recent efforts attempt to correlate resistance mutations in new subfamilies of oxacillinases for the design of new antimicrobial agents.

Furthermore, we are focusing in the structural characterization of the AbkA/AbkB toxin-antitoxin system in A. baumannii, related to virulence and involved in the successful dissemination of plasmids carrying the blaOXA-24/40-like gene, thus contributing to the plasmid stability.