We are interested in the study of intermediate filament proteins of the type III family as sensors for electrophilic and oxidative stress. This involves the characterization of their posttranslational modifications under these conditions and the assessment of their functional consequences.
In this process, we are interested in exploring novel roles and interactions for these proteins, both in basic cellular events and in disease. In particular, we are exploring the consequences of mutations in GFAP associated with Alexander disease, a rare neurodegenerative disease.
In the figure, half of a mitotic cell is shown, illustrating the distribution of cortical actin (red) and vimentin filaments (green). Image modified from Nat Commun (2019) 10: 4200. Doi: 10.1038/s41467-019-12029-4.