RMN Biomolecular | Centro de Investigaciones Biológicas Margarita Salas - CIB Margarita Salas

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Head of lab

Francisco Jose Blanco Gutierrez

Ver Proyectos actuales Ver Proyectos anteriores

Molecular recognition in DNA replication and repair

Structure-function of ING tumor suppressors

Targeting non-GPCR regulation of G proteins to stop cancer

Personal Científico
Francisco Jose Blanco Gutierrez

Postdoctorals
Belen Chaves Arquero

Técnicos
Miriam Barbera Sanchez

Predoctorales
Maria de la O Ferreras Gutierrez
Antonio Ruiz Albor

Group

Ferreras-Gutiérrez M, Chaves-Arquero B, González-Magaña M, Merino N, Amusategui-Mateu I, Huecas S, Medrano FJ, Blanco FJ [2023]. Structural analysis of ING3 protein and histone H3 binding. Int J Biol Macromol (124724).

Jingyi Zhao, Vincent DiGiacomo, Mariola Ferreras-Gutierrez, Shiva Dastjerdi, Alain Ibáñez de Opakua, Jong-Chan Park, Alex Luebbers, Qingyan Chen, Aaron Beeler, Francisco J. Blanco, and Mikel Garcia-Marcos. [2023]. Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer. PNAS 120 (18) e2213140120.

Laura Rubio-Pérez, Rodrigo Lázaro-Gorines, Seandean L. Harwood, Marta Compte, Rocío Navarro, Antonio Tapia-Galisteo, Jaume Bonet, Belén Blanco, Simon Lykkemark, Ángel Ramírez-Fernández, Mariola Ferreras-Gutiérrez, Carmen Domínguez-Alonso, Laura Díez-Alonso, Alejandro Segura-Tudela, Oana Hangiu, Ainhoa Erce-Llamazares, Francisco J. Blanco, Cruz Santos, José L. Rodríguez-Peralto, Laura Sanz & Luis Álvarez-Vallina. [2023]. A PD-L1/EGFR bispecific antibody combines immune checkpoint blockade and direct anti-cancer action for an enhanced anti-tumor response. OncoImmunology 12,1.

Liu J, Chaves-Arquero B, Wei P, Tencer AH, Ruiz-Albor A, Zhang G, Blanco FJ, Kutateladze TG [2023]. Molecular insight into the PCNA-binding mode of FBH1. Structure 31, 1-7.

Cano A, Vazquez-Chantada M, Conde-Vancells J, Gonzalez-Lahera A, Mosen-Ansorena D, Blanco FJ, Clément K, Aron-Wisnewsky J, Tran A, Gual P, García-Monzón C, Caballería J, Castro A, Martínez-Chantar ML, Mato JM, Zhu H, Finnell RH, Aransay AM [2023]. Impaired Function of Solute Carrier Family 19 Leads to Low Folate Levels and Lipid Droplet Accumulation in Hepatocytes. Biomedicines 11(2), 337.

O Hangiu, M Compte, A Dinesen, R Navarro, A Tapia-Galisteo, OA Mandrup, A Erce-Llamazares, R Lázaro-Gorines, D Nehme-Álvarez, C Domínguez-Alonso, SL Harwood, C Alfonso, B Blanco, L Rubio-Pérez, A Jiménez-Reinoso, L Díez-Alonso, FJ Blanco, L Sanz, KA Howard, L Álvarez-Vallina [2022]. A tumor target-dependent 4-1BB agonist antibody fused to albumin engineered for enhanced FcRn binding induces anti-tumor immunity without toxicity. iScience 25, 104958.

B Chaves-Arquero, C Persson, N Merino, J Tomás-Cortazar, AL Rojas, J Anguita, FJ Blanco [2022]. Structural Analysis of the Black-Legged Tick Saliva Protein Salp15. International Journal of Molecular Sciences. 23, 3134.

Tapia-Galisteo A, Sánchez Rodríguez Í, Aguilar-Sopeña O, Harwood SL, Narbona J, Ferreras Gutierrez M, Navarro R, Martín-García L, Corbacho C, Compte M, Lacadena J, Blanco FJ, Chames P, Roda-Navarro P, Álvarez-Vallina L, Sanz L [2022]. Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer. OncoImmunology. 11:2034355.

Compte M, Harwood SL, Erce-Llamazares A, Tapia-Galisteo A, Romero E, Ferrer I, Garrido-Martin EM, Enguita AB, Ochoa MC, Blanco B, Oteo M, Merino N, Nehme-Álvarez D, Hangiu O, Domínguez-Alonso C, Zonca M, Ramírez-Fernández A, Blanco FJ, Morcillo MA, Muñoz IG, Melero I, Rodriguez-Peralto JL, Paz-Ares L, Sanz L, Alvarez-Vallina L [2021]. An Fc-free EGFR-specific 4-1BB-agonistic Trimerbody Displays Broad Antitumor Activity in Humanized Murine Cancer Models without Toxicity. Clin Cancer Res 27, 3167-3177.

Romero JA, Nawrocka EK, Shchukina A, Blanco FJ, Diercks T, Kazimierczuk K [2020]. Non‐Stationary Complementary Non‐Uniform Sampling (NOSCO NUS) for Fast Acquisition of Serial 2D NMR Titration Data. Angew Chem Int Ed Engl 132, 23702.

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