Chemical and Physical Biology
Research Departments

Home Departments Chemical and Physical Biology

Description

A major challenge for Biology in the 21st century is to reach the quantitative level of Physics and Chemistry. Following this trend, the main research goal of CPB is to develop a quantitative understanding of specific biological problems at different levels of complexity, from the single molecule level to sub-cellular macromolecular assemblies. This knowledge will enable to predict, control and engineer essential biological functions towards biomedical and/or biotechnological applications. In order to meet these challenges, CPB line gathers a powerful combination of strengths in Structural Biology, Mechanistic Biochemistry, Molecular Biophysics, and Computational Biology that is organized in two sublines: i) Structural and Quantitative Biology and ii) Biomolecular Recognition and Assembly. Methodologically, research at CPB involves the combination of physical chemical and biological methods to attain high-resolution structural, temporal and ensemble (single molecule versus collective behavior) information of the molecular events controlling biological phenomena with well-established expertise in the identification, isolation, quantitative characterization, modification, and engineering of peptides, proteins and macromolecular assemblies involved in essential cellular processes. CPB research efforts range from fundamental processes (such as protein structure, folding, aggregation and evolution, protein function and regulation, energetics and dynamics of biomolecular interactions), to more applied efforts towards developing new substances with pharmacological interest, such as new antibiotics. These projects cover from the structural and functional analysis of specific biological problems (such as DNA replication and repair, cell division, cancer, angiogenesis, antibiotic action and resistance, programmed cell-death, post-translational modifications, and chromatin structure) to the in vitro reconstitution and engineering of sub-cellular macromolecular machines.  The CPB line aims to combine these research efforts and multidisciplinary expertise into a common structure fostering collaboration within CPB and with other researchers at CIB and outside, and optimization of the large-scale instrument infrastructure required for this research.


Research Groups

  • Eukaryotic antibiotic peptides

  • Microtubule stabilizing agents

  • Posttranslational modification of proteins

  • Tubulins and FtsZ: targeting protein self-assembly

  • Electron Microscopy and Three Dimensional Reconstruction of Macromolecules

  • NMR and molecular recognition

  • Structural Biology of Host-Pathogen Interactions

  • Structural Biology of Proteins

  • Structure of Macromolecular Assemblies

  • Translational Medicinal and Biological Chemistry


  • Department's Seminar

    There are not programmed seminars by this Department

    Head of department:
    Jiménez Barbero, Jesús

    Staff Scientists
    Andreu Morales, José Manuel
    Barasoain Blasco, Isabel
    Campillo Martin, Nuria Eugenia
    Cañada Vicinay, Francisco Javier
    Díaz Pereira, José Fernando
    Fernández Tornero, Carlos
    Fernández de Palencia Delgado, Pilar
    Gil Ayuso-Gontan, Carmen
    Giménez Gallego, Guillermo
    Jiménez Barbero, Jesús
    Llorca Blanco, Oscar Antonio
    Martinez Gil, Ana
    Pérez-Sala Gozalo, Dolores
    Rivas López, Luis Ignacio
    Romero Garrido, Antonio
    Vega Fernández, María Cristina

    Technical Staff
    Alonso Gil, Sandra
    Davó Siguero, Irene
    Díaz Hernández, María Dolores
    Huecas Gayo, Sonia
    Perez Fernandez, Daniel Ignacio
    Redondo Horcajo, Mariano

    Postdoctorals
    Abengozar Infantes, Mª Angeles
    Alcorlo Pages, Martín
    Araujo Bazán, Lidia
    Arda Freire, Ana
    Fernández Alonso, Mª del Carmen
    Fernández Pérez, Francisco José
    Fernández Tejada, Alberto
    Garcia Puentes, Diego
    Medrano Martín, Francisco Javier
    Melero Del Rio, Roberto
    Oliva Blanco, María Ángela
    Ruiz , Federico Martín
    Sánchez Gómez, Francisco Javier
    Spinola Amilibia, María Mercedes

    Postgraduates
    Alegrio Louro, Jaime Manuel
    Berbis Moreno, Manuel Alvaro
    Castillo Tutor, Nuria
    Flores Ibarra, Andrea
    Galante , Silvia
    Garcia Fernandez, Ana Maria
    Garcia Salado, Maria Irene
    González Corrochano, Rocio
    López Estepa, Miguel
    López Perrote, Andrés
    Marcelo , Filipa Margarida
    Muñoz Hernández, Hugo
    Oeste Villavieja, Clara Lillian
    Querol García, Javier
    Ramírez Aportela, Erney
    Reyes Rodriguez, Julio Alberto
    Rivera Calzada, Angel
    Rodríguez Salarichs, Javier
    Sáez Calvo, Gonzalo
    Sastre Martínez, Javier
    Unione , Luca
    Vergoñós Tomàs, Albert
    Yébenes Revuelto, Hugo

    Visiting Scientists
    Antunez Mojica, Mayra Yaneth
    Babuadze , George
    Canales Mayordomo, Mª Ángeles
    Castellen , Patricia
    Di Martino , Rita Maria Concetta
    Dominguez Caro, Jaime
    Escudero Fernandez, Raquel
    Fernandez de Toro Ronda, Beatriz
    Gonzalez Morena, Juan Manuel
    Gonzalez Pelayo, Silvia
    Iriberri Leonor, Paula
    Lopes Lima, Marta
    Martin Español, Carlos
    Martinez Lopez, Marta
    Ortega Nogales, Francisco Jesús
    Rojas Prats, Elisa
    Ruiz Ávila, Laura
    Sanz Murillo, Marta María
    Taylor , Nicholas
    Viedma Poyatos, Alvaro
    Zaldivar Diez de Bonilla, Josefa

    Technician
    Arroyo Nombela, Margarita
    Carrasco Soto, María Jesús
    Carrascosa Cebrián, Margarita
    Juan Rodríguez, David
    Santillana Heras, Elena
    Torreira Ontiveros, Eva María

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    How to find us

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    Ramiro de Maeztu 9, 28040 Madrid

    Telephone +34 91 837 31 12 | Fax +34 91 536 04 32

    Ministerio de educación y ciencia